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Clinical Significance and Different Expression of Dipeptidyl Peptidase Iv and Procalcitonin in Mild and Severe Covid-19 Publisher



Jamaati H1 ; Tabarsi P2 ; Bahrami N3, 4 ; Yasari F1 ; Varahram M5 ; Dizaji MK6 ; Hashemian SMR1 ; Daustani M7 ; Emami M1 ; Shirian S8, 9, 10 ; Masumi L11 ; Rasouli A12 ; Narimani A13 ; Ahmadian N14 Show All Authors
Authors
  1. Jamaati H1
  2. Tabarsi P2
  3. Bahrami N3, 4
  4. Yasari F1
  5. Varahram M5
  6. Dizaji MK6
  7. Hashemian SMR1
  8. Daustani M7
  9. Emami M1
  10. Shirian S8, 9, 10
  11. Masumi L11
  12. Rasouli A12
  13. Narimani A13
  14. Ahmadian N14
  15. Mohamadnia A1, 15
  16. Velayati AA5

Source: Journal of Cellular and Molecular Anesthesia Published:2021


Abstract

Background: Coronavirus has become a global concern in 2019-20. The virus belongs to the coronavirus family, which has been able to infect many patients and victims around the world. The virus originated in the Chinese city of Wuhan, which eventually spread around the world and became a pandemic. Materials and Methods: A total of 60 Patients with severe (n=30) and mild (n=30) symptoms of COIVD-19 were included in this study. Peripheral blood samples were collected from the patients. Real-time PCR was used to compare the relative expression levels of Procalcitonin and dipeptidyl peptidase IV (DPPIV) in a patient with severe and mild Covid-19 infection. Results: Procalcitonin and dipeptidyl peptidase IV markers in the peripheral blood of patients with severe symptoms, were positive in 29 (96.60%) and 26 (86.60%), respectively (n=30); however, positive rates in the mild symptoms patients group were 27 (90%) and 25 (83.30%), respectively. There was a statistically significant difference between these two groups in terms of DDPIV and Procalcitonin (p<0.001). Conclusion: Procalcitonin and DPPIV increase in patients with COVID-19 infection, significantly higher in the patients with more severe clinical symptoms than those with milder ones. More studies will be needed to verify the reliability of the current findings. © 2021 Vaclav Skala Union Agency. All right reserved.
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