Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Protective and Pathological Roles of Regulatory Immune Cells in Human Cytomegalovirus Infection Following Hematopoietic Stem Cell Transplantation Publisher Pubmed



Namdari H1 ; Hosseini M2 ; Yazdanifar M3 ; Farajifard H1 ; Parvizpour F1 ; Karamigolbaghi M1 ; Hamidieh AA2 ; Rezaei F4
Authors

Source: Reviews in Medical Virology Published:2022


Abstract

Human cytomegalovirus (HCMV) is ubiquitously prevalent. Immune system in healthy individuals is capable of controlling HCMV infection; however, HCMV can be life-threatening for immunocompromised individuals, such as transplant recipients. Both innate and adaptive immune systems are critically involved in the HCMV infection. Recent studies have indicated that regulatory immune cells which play essential roles in maintaining a healthy immune environment are closely related to immune response in HCMV infection. However, the exact role of regulatory immune cells in immune regulation and homoeostasis during the battle between HCMV and host still requires further research. In this review, we highlight the protective and pathological roles of regulatory immune cells in HCMV infection following hematopoietic stem cell transplantation (HSCT). © 2021 John Wiley & Sons Ltd.
Related Docs
View other Related Docs
1. Efficacy and Safety of Adoptive T-Cell Therapy in Treating Cytomegalovirus Infections Post-Haematopoietic Stem Cell Transplantation: A Systematic Review and Meta-Analysis, Reviews in Medical Virology (2024)
2. Co-Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells With Hematopoietic Stem Cells Does Not Improve Transplantation Outcome in Class Iii Beta-Thalassemia Major: A Prospective Cohort Study With Long-Term Follow-Up, Pediatric Transplantation (2021)
3. Human Cytomegalovirus Micrornas: Strategies for Immune Evasion and Viral Latency, Archives of Virology (2024)
Experts (# of related papers)
View all Related Experts
Mohammad Ahmadvand (2)
Ali Akbar Amirzargar (2)
Other Related Docs
4. The Role of Interleukin-2 in Graft-Versus-Host Disease Pathogenesis, Prevention and Therapy, Cytokine (2024)
5. Monitoring Human Cytomegalovirus Infection in Pediatric Hematopoietic Stem Cell Transplant Recipients: Using an Affordable In-House Qpcr Assay for Management of Hcmv Infection Under Limited Resources, Transplant International (2015)
6. Transcriptomic Analysis of Human Cytomegalovirus to Survey the Indirect Effects on Renal Transplant Recipients, Transplant Immunology (2023)
7. Overview and Recent Advances of Regulatory T Cell Therapy in Solid Organ Transplantation, Iranian Journal of Kidney Diseases (2021)
8. In Vitro Generation of Bk Polyomavirus-Specific T Cells for Adoptive Cell Therapy in Refractory Cystitis Hemorrhagic Patients After Hematopoietic Stem Cell Transplantation, BMC Immunology (2022)
9. Cell Therapy in Transplantation: A Comprehensive Review of the Current Applications of Cell Therapy in Transplant Patients With the Focus on Tregs, Car Tregs, and Mesenchymal Stem Cells, International Immunopharmacology (2021)
10. Mesenchymal Stem Cell Transplantation in Newly Diagnosed Type-1 Diabetes Patients: A Phase I/Ii Randomized Placebo-Controlled Clinical Trial, Stem Cell Research and Therapy (2022)
11. Spotlight on the Impact of Viral Infections on Hematopoietic Stem Cells (Hscs) With a Focus on Covid-19 Effects, Cell Communication and Signaling (2023)
12. F Protein Increases Cd4+Cd25+ T Cell Population in Patients With Chronic Hepatitis C, Pathogens and Disease (2015)
13. Association of Il-15 and Ip-10 Serum Levels With Cytomegalovirus Infection, Cmv Viral Load and Cyclosporine Level After Kidney Transplantation, Reports of Biochemistry and Molecular Biology (2021)
14. Deciphering Host–Virus Interactions and Advancing Therapeutics for Chronic Viral Infection, Viruses (2025)
15. The Role of Nk Cells and Their Exosomes in Graft Versus Host Disease and Graft Versus Leukemia, Stem Cell Reviews and Reports (2023)
16. Cytomegalovirus and Its Role in Congenital Infection: A Narrative-Review Study, Iranian Journal of Obstetrics# Gynecology and Infertility (2020)
17. Active Cmv and Ebv Infections in Renal Transplant Recipients With Unexplained Fever and Elevated Serum Creatinine, Renal Failure (2016)
18. Hepatitis B Immunopathogenesis and Immunotherapy, Immunotherapy (2016)
19. Cracking the Human Cytomegalovirus Code: Trinary Challenges of Latency, Immune Evasion, and Correlates of Protection, Iranian Journal of Allergy, Asthma and Immunology (2025)
20. The Promising Approach of Mscs Therapy for Covid-19 Treatment, Cell and Tissue Banking (2023)