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Synthesis and Characterization of 1-Amidino-O-Alkylureas Metal Complexes As Α- Glucosidase Inhibitors: Structure-Activity Relationship, Molecular Docking, and Kinetic Studies Publisher



Moghaddam FM1 ; Daneshfar M1 ; Daneshfar Z2 ; Iraji A3, 4 ; Samandarinajafabad A5 ; Faramarzi MA6 ; Mahdavi M5
Authors

Source: Journal of Molecular Structure Published:2022


Abstract

In the present study, metal complexes of 1-amidino-O-alkylureas were designed, synthesized and characterized by elemental analyses, FT-IR spectra, XRD, Mass analyses and scanning electron microscopy (SEM). All synthesized complexes were screen as α-Glucosidase inhibitors. According to the in vitro results, the Cu (II) complexes showed superior potency compared to other tested metal complexes. Particularly, [Cu(L-Me)2](Cl)2 (1b) showed the strongest inhibition against α-Glucosidase with an IC50 value of 2.75 ± 0.3 µM which was comparable to that of acarbose (IC50 = 750 µM). These findings are supported by the ligands and enzyme interactions through molecular docking. © 2021 Elsevier B.V.
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