The Chemical Composition and Anti-Mycobacterial Activities of Trachyspermum Copticum and Pelargonium Graveolens Essential Oils Publisher Pubmed



Kardanyamchi J^{1, 2} ; Mahboubi M³ ; Kazemian H^{4, 5} ; Hamzelou G⁶ ; Feizabadi MM^{2, 7}
Source: Recent Patents on Anti-Infective Drug Discovery Published:2020

Abstract

Background: Microbial resistance to antibiotics and their adverse effects related to these antibiotics are a matter of global public health in the 21th century. The emergence of drug-resistant strains, has gained the interest of the scientists to discover new antimicrobial agents from the essential oil of medicinal plants. Methods: Anti-mycobacterial effects of Trachyspermum copticum and Pelargonium gra-veolens essential oils were determined against multi-drug resistant clinical strains of Myco-bacterium tuberculosis, Mycobacterium kansasii, Mycobacterium fortuitum and standard strain of Mycobacterium tuberculosis H37Rv by a Broth micro-dilution method. Pelargoni-um graveolens plant named Narmada was discovered by Kulkarni R.N et al. (Patent ID, USPP12425P2) and a formulation comprising thymol obtained from Trachyspermum is useful in the treatment of drug-resistant bacterial infections (Patent ID, US6824795B2). The chemical composition of hydro-distilled essential oils was determined by GC and GC-MS. Results: Minimum Inhibitory Concentration (MIC) values for T. copticum essential oil against tested isolates were ranged from 19.5 μg/mL to 78 μg/mL. The least minimum in-hibitory concentration of P. graveolens extract against M. Kansasii and MDR-TB was 78 μg/ml. Conclusion: The results of the present research introduced T. copticum and P. graveolens essential oils as a remarkable natural anti-mycobacterial agent, but more pharmacological studies are required to evaluate their efficacy in animal models. © 2020 Bentham Science Publishers.