Atopic March in a Case of Filaggrin Gene Mutation Publisher



Razaghian A^{1, 2} ; Moradi L^{2, 3} ; Allahverdi B⁴ ; Khansari Asadabadi M^{2, 3} ; Alizadeh Z^{2, 3} ; Shokouhi Shoormasti R^{2, 3} ; Fazlollahi M^{2, 3}
Source: Pediatric, Allergy, Immunology, and Pulmonology Published:2025

Abstract

Introduction: The atopic march refers to the progression of allergic disorders from atopic dermatitis (AD) in early childhood to food allergies, eosinophilic esophagitis (EOE), and later respiratory allergies such as asthma and allergic rhinitis. Mutations in the filaggrin gene, which compromise skin barrier function, are strongly associated with this progression and contribute to allergic sensitization. Case Presentation: We introduce a 7-year-old boy with severe AD, food anaphylaxis, EOE, allergic rhinitis, and asthma associated with a filaggrin mutation (c.5152C>T). His clinical course illustrates the atopic march, with initial skin involvement progressing to gastrointestinal and respiratory allergic manifestations. Conclusion: Understanding the genetic factors that drive this progression may help identify targets for early intervention to prevent the further development of allergic disease. Copyright 2025, Mary Ann Liebert, Inc., publishers.