Synthesis of Furan-Linked Iminomethyl 2-Aminochromones Via a Base-Promoted Cascade Reaction of 3-Cyanochromones With Β-Ketodinitriles

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Synthesis of Furan-Linked Iminomethyl 2-Aminochromones Via a Base-Promoted Cascade Reaction of 3-Cyanochromones With Β-Ketodinitriles Publisher Pubmed

Farajpour B ; Khawari F ; Davoudi NB ; Lotfi Nosood Y ; Notash B ; Taheri S ; Moradkhani F ; Shiri M ; Alharrasi A ; Hussain FHS

Source: Organic and Biomolecular Chemistry Published:2025

Abstract

A base-promoted reaction of 3-cyanochromones with β-ketodinitriles has been described to afford novel furan-linked iminomethyl 2-aminochromone derivatives in an efficient manner. This cascade reaction involves multiple transformations including the in situ generation of a 2-amino-furan intermediate/Michael-type addition/retro-Michael-type ring opening process/intramolecular O-cyclization/tautomerization under simple heating conditions. This facile process is distinguished by its operational simplicity, excellent atom efficiency, good functional group compatibility, easy purification, synthetically useful yields, and applicability for gram-scale synthesis. This journal is © The Royal Society of Chemistry, 2025

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Style	Citing Format
MLA	Farajpour B, et al.. "Synthesis of Furan-Linked Iminomethyl 2-Aminochromones Via a Base-Promoted Cascade Reaction of 3-Cyanochromones With Β-Ketodinitriles." Organic and Biomolecular Chemistry, vol. 23, no. 48, 2025, pp. 10922-10928.
APA	Farajpour B, Khawari F, Davoudi NB, Lotfi Nosood Y, Notash B, Taheri S, Moradkhani F, Shiri M, Alharrasi A, Hussain FHS (2025). Synthesis of Furan-Linked Iminomethyl 2-Aminochromones Via a Base-Promoted Cascade Reaction of 3-Cyanochromones With Β-Ketodinitriles. Organic and Biomolecular Chemistry, 23(48), 10922-10928.
Chicago	Farajpour B, Khawari F, Davoudi NB, Lotfi Nosood Y, Notash B, Taheri S, Moradkhani F, Shiri M, Alharrasi A, Hussain FHS. "Synthesis of Furan-Linked Iminomethyl 2-Aminochromones Via a Base-Promoted Cascade Reaction of 3-Cyanochromones With Β-Ketodinitriles." Organic and Biomolecular Chemistry 23, no. 48 (2025): 10922-10928.
Harvard	Farajpour B et al. (2025) 'Synthesis of Furan-Linked Iminomethyl 2-Aminochromones Via a Base-Promoted Cascade Reaction of 3-Cyanochromones With Β-Ketodinitriles', Organic and Biomolecular Chemistry, 23(48), pp. 10922-10928.
Vancouver	Farajpour B, Khawari F, Davoudi NB, Lotfi Nosood Y, Notash B, Taheri S, et al.. Synthesis of Furan-Linked Iminomethyl 2-Aminochromones Via a Base-Promoted Cascade Reaction of 3-Cyanochromones With Β-Ketodinitriles. Organic and Biomolecular Chemistry. 2025;23(48):10922-10928.
BibTex	@article{ author = {Farajpour B and Khawari F and Davoudi NB and Lotfi Nosood Y and Notash B and Taheri S and Moradkhani F and Shiri M and Alharrasi A and Hussain FHS}, title = {Synthesis of Furan-Linked Iminomethyl 2-Aminochromones Via a Base-Promoted Cascade Reaction of 3-Cyanochromones With Β-Ketodinitriles}, journal = {Organic and Biomolecular Chemistry}, volume = {23}, number = {48}, pages = {10922-10928}, year = {2025} }
RIS	TY - JOUR AU - Farajpour B AU - Khawari F AU - Davoudi NB AU - Lotfi Nosood Y AU - Notash B AU - Taheri S AU - Moradkhani F AU - Shiri M AU - Alharrasi A AU - Hussain FHS TI - Synthesis of Furan-Linked Iminomethyl 2-Aminochromones Via a Base-Promoted Cascade Reaction of 3-Cyanochromones With Β-Ketodinitriles JO - Organic and Biomolecular Chemistry VL - 23 IS - 48 SP - 10922 EP - 10928 PY - 2025 ER -

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