Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Metabolic Connectivity in Alzheimer’S Diseases Publisher



Rahmani F1, 2 ; Sanjari Moghaddam H3 ; Rahmani M2 ; Aarabi MH3
Authors

Source: Clinical and Translational Imaging Published:2020


Abstract

Multiple studies have investigated the disruptions in structural and functional connectivity in aging, dementia and Alzheimer’s disease (AD). The study of metabolic connectivity between brain regions using fluorodeoxyglucose positron emission tomography (FDG-PET) however, is a new focus of interest. Several methodological approaches, including seed-based correlation, independent and principal component analysis, and graph-theoretical approaches have been employed to study the metabolic disconnectivity in AD. We conducted a systematic search of the literature using the keywords metabolic connectivity and Alzheimer disease, up to the date of last submission and included 15 original articles as relevant. Existing literature implies a generalized metabolic disconnectivity in the brain which closely follow findings from functional studies. In the following review, we introduce the concept of metabolic disconnectivity and discuss the alterations in metabolic connectivity in AD and the potential underlying mechanisms. We find it imperative for future studies to investigate alterations in metabolic and functional connectome of AD and mild cognitive disorder through simultaneous acquisition of FDD-PET, functional and structural scans. © 2020, Italian Association of Nuclear Medicine and Molecular Imaging.
Other Related Docs
11. Cortical and Subcortical Structural Segmentation in Alzheimer’S Disease, Frontiers in Biomedical Technologies (2019)
20. Characterization of Brain Functional Connectivity in Treatment-Resistant Depression, Progress in Neuro-Psychopharmacology and Biological Psychiatry (2021)