Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Toxigenic Clostridium Difficile-Mediated Diarrhoea in Hematopoietic Stem Cell Transplantation In-Patients: Rapid Diagnosis and Efficient Treatment Publisher Pubmed



Khodaparast S1 ; Mohabati Mobarez A1 ; Khoramabadi N1 ; Vasei M2 ; Saberifiroozi M3
Authors

Source: Epidemiology and Infection Published:2021


Abstract

Allogenic hematopoietic stem cell transplant (HSCT) recipients are susceptible to any kind of infectious agents including Clostridium difficile. We studied 86 allogenic-HSCT patients who faced diarrhoea while receiving antibiotics. DNA from stool samples were explored for the presence of C. difficile toxin genes (tcdA; tcdB) by multiplex real-time PCR. Results showed nine toxigenic C. difficile amongst which seven were positive for both toxins and two were positive for tcdB. Six of toxigenic C. difficile organisms harbouring both toxin genes were also isolated by toxigenic culture. Clostridium difficile infection was controlled successfully with oral Metronidazole and Vancomycin in the confirmed infected patients. Copyright © The Author(s), 2021. Published by Cambridge University Press.
Related Docs
View other Related Docs
1. Antibiotic-Associated Diarrhea Mediated by Toxigenic Clostridioides Difficile Infection in Iran: A Clinical Survey by Multiplex Real-Time Polymerase Chain Reaction and Toxigenic Culture, Govaresh (2022)
2. A Two-Step Approach for Diagnosing Glutamate Dehydrogenase Genes by Conventional Polymerase Chain Reaction From Clostridium Difficile Isolates, Middle East Journal of Digestive Diseases (2019)
3. Anti-Tnf Containing Regimens May Be Associated With Increased Risk of Clostridioides Difficile Infection in Patients With Underlying Inflammatory Bowel Disease, Current Research in Translational Medicine (2020)
Experts (# of related papers)
View all Related Experts
Masoumeh Douraghi (8)
Mohammad Ali Boroumand (2)
Other Related Docs
4. Rapid Simultaneous Molecular Stool-Based Detection of Toxigenic Clostridioides Difficile by Quantitative Taqman Real-Time Pcr Assay, Clinical Laboratory (2019)
5. Isolation and Characterization of a Multidrug-Resistant Clostridioides Difficile Toxinotype V From Municipal Wastewater Treatment Plant, Journal of Environmental Health Science and Engineering (2020)
6. Pathogenicity Locus Determinants and Toxinotyping of Clostridioides Difficile Isolates Recovered From Iranian Patients, New Microbes and New Infections (2018)
7. Molecular Typing of Clostridioides Difficile Isolates From Clinical and Non-Clinical Samples in Iran, APMIS (2019)
8. High Prevalence of Clostridiodes Diffiicle Pcr Ribotypes 001 and 126 in Iran, Scientific Reports (2020)
9. Highly Antibiotic-Resistant Clostridium Difficile Isolates From Iranian Patients, Journal of Applied Microbiology (2018)
10. Fecal Microbiota Transplantation for Recurrent Clostridium Difficile Infection in Patients With Inflammatory Bowel Disease; Case Series, Govaresh (2017)
11. Significant Presence of Clostridioides Difficile in Colorectal Cancer Patients by Taqman Real-Time Pcr, Iranian Journal of Medical Microbiology (2024)
12. Characterization of Clostridioides Difficile Isolates Recovered From Hospitalized Patients and the Hospitals Environment and Air: A Multicenter Study, Anaerobe (2019)
13. The Emergence of Metronidazole and Vancomycin Reduced Susceptibility in Clostridium Difficile Isolates in Iran, Journal of Global Antimicrobial Resistance (2019)
14. The Rate and Importance of Clostridium Difficile in Colorectal Cancer Patients, Gastroenterology and Hepatology from Bed to Bench (2019)
15. Evaluation of Cellular Response to Clostridium Difficile Toxin-A: A Network Analysis, Gastroenterology and Hepatology from Bed to Bench (2022)
16. Detection of Cdtb Gene Among Enteric Bacteria in Patients With Gastroenteritis and Irritable Bowel Syndrome, Koomesh (2019)
17. Fecal Microbiota Transplantation for Recurrent Clostridioides Difficile Infection in Patients With Concurrent Ulcerative Colitis, Acta Microbiologica et Immunologica Hungarica (2021)
18. Intestinal Microbiota Changes Pre- and Post-Fecal Microbiota Transplantation for Treatment of Recurrent Clostridioides Difficile Infection Among Iranian Patients With Concurrent Inflammatory Bowel Disease, Frontiers in Microbiology (2023)
19. Carriage of Cdtb Encoding Campylobacter Spp., Salmonella Enterica, and Yersinia Entercolitica in Patients With Gastroenteritis and Irritable Bowel Syndrome, Digestive Diseases and Sciences (2022)
20. Clinical and Pathological Features of Ulcerative Colitis in Patients With and Without Clostridium Difficile Infection; an Observational Study, Middle East Journal of Digestive Diseases (2019)