Chitosan Grafted Onto Fe3o4@Poly(: N -Vinylcaprolactam) As a New Sorbent for Detecting Imatinib Mesylate in Biosamples Using Uplc-Ms/Ms

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Chitosan Grafted Onto Fe3o4@Poly(: N -Vinylcaprolactam) As a New Sorbent for Detecting Imatinib Mesylate in Biosamples Using Uplc-Ms/Ms Publisher Pubmed

Sahebi H¹ ; Pourmortazavi SM² ; Zandavar H² ; Mirsadeghi S³

Source: Analyst Published:2019

Abstract

Fe3O4 nanoparticles with chitosan grafted onto poly(N-vinylcaprolactam) copolymers are synthesized and showed dual sensitivity to temperature and pH. The nanoparticles were characterized by different techniques and two aspects of their applications were evaluated using Imatinib mesylate drug as a model. The first studied application of these nanoparticles was the extraction and pre-concentration of Imatinib mesylate from biological samples. Parameters such as sorbent dosage and extraction and desorption time can affect Imatinib mesylate extraction and were studied by Box-Behnken design and response surface methodology, while the one-factor-at-a-time approach was used to assessed the sample pH and elution solvent type and amount. The determination and quantification were accomplished by ultra-performance liquid chromatography-mass spectrometry. The limit of quantification of the approach was 1.0 ng mL-1. Inter/intraday precision was obtained as 3.4-6.7% and 5.1-7.7%, respectively. Also, the modified nanoparticles were studied in basic in vitro drug delivery research which led to satisfactory results. © 2019 The Royal Society of Chemistry.

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Style	Citing Format
MLA	Sahebi H, et al.. "Chitosan Grafted Onto Fe3o4@Poly(: N -Vinylcaprolactam) As a New Sorbent for Detecting Imatinib Mesylate in Biosamples Using Uplc-Ms/Ms." Analyst, vol. 144, no. 24, 2019, pp. 7336-7350.
APA	Sahebi H, Pourmortazavi SM, Zandavar H, Mirsadeghi S (2019). Chitosan Grafted Onto Fe3o4@Poly(: N -Vinylcaprolactam) As a New Sorbent for Detecting Imatinib Mesylate in Biosamples Using Uplc-Ms/Ms. Analyst, 144(24), 7336-7350.
Chicago	Sahebi H, Pourmortazavi SM, Zandavar H, Mirsadeghi S. "Chitosan Grafted Onto Fe3o4@Poly(: N -Vinylcaprolactam) As a New Sorbent for Detecting Imatinib Mesylate in Biosamples Using Uplc-Ms/Ms." Analyst 144, no. 24 (2019): 7336-7350.
Harvard	Sahebi H et al. (2019) 'Chitosan Grafted Onto Fe3o4@Poly(: N -Vinylcaprolactam) As a New Sorbent for Detecting Imatinib Mesylate in Biosamples Using Uplc-Ms/Ms', Analyst, 144(24), pp. 7336-7350.
Vancouver	Sahebi H, Pourmortazavi SM, Zandavar H, Mirsadeghi S. Chitosan Grafted Onto Fe3o4@Poly(: N -Vinylcaprolactam) As a New Sorbent for Detecting Imatinib Mesylate in Biosamples Using Uplc-Ms/Ms. Analyst. 2019;144(24):7336-7350.
BibTex	@article{ author = {Sahebi H and Pourmortazavi SM and Zandavar H and Mirsadeghi S}, title = {Chitosan Grafted Onto Fe3o4@Poly(: N -Vinylcaprolactam) As a New Sorbent for Detecting Imatinib Mesylate in Biosamples Using Uplc-Ms/Ms}, journal = {Analyst}, volume = {144}, number = {24}, pages = {7336-7350}, year = {2019} }
RIS	TY - JOUR AU - Sahebi H AU - Pourmortazavi SM AU - Zandavar H AU - Mirsadeghi S TI - Chitosan Grafted Onto Fe3o4@Poly(: N -Vinylcaprolactam) As a New Sorbent for Detecting Imatinib Mesylate in Biosamples Using Uplc-Ms/Ms JO - Analyst VL - 144 IS - 24 SP - 7336 EP - 7350 PY - 2019 ER -

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