Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Synthesis and Biological Evaluation of 1,3,4,5-Tetrasubstituted Pyrazole Derivatives Publisher



Yahyavi H1, 3 ; Hosseinzadeh F1 ; Karimi N1 ; Moghimi S1 ; Mahdavi M2 ; Nadri H4 ; Moradi A4 ; Shafiee A1 ; Foroumadi A1, 2
Authors

Source: Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences Published:2016


Abstract

We report a solvent-free synthesis of novel 1,3,4,5-tetrasubstituted pyrazoles and investigate their inhibitory activity against soybean 15-lipoxygenase. It was revealed that all synthesized compounds exhibited good activity, and among them, 3-(furan-2-yl)-1,4,5-triphenyl-1H-pyrazole (5j) showed 10 times stronger inhibitory activity in comparison to the reference drug quercetin. © 2016, Verlag der Zeitschrift fur Naturforschung. All rights reserved.
Related Docs
View other Related Docs
1. Synthesis of Thiazolone Derivatives As Novel Soybean 15-Lox Inhibitors, Letters in Organic Chemistry (2017)
2. Synthesis and Evaluation of Coumarin-Resveratrol Hybrids As 15-Lipoxygenaze Inhibitors, Synthetic Communications (2015)
3. Novel Pyrano[3,2-C]Quinoline-1,2,3-Triazole Hybrids As Potential Anti-Diabetic Agents: In Vitro Α-Glucosidase Inhibition, Kinetic, and Molecular Dynamics Simulation, ACS Omega (2023)
Experts (# of related papers)
View all Related Experts
Mohammad Mahdavi (13)
Mohammad Ali Faramarzi (7)
Other Related Docs
4. Synthesis, Reaction and Biological Activity of Pyrazolo[5,1-C][1,2,4]Benzotriazine 5-Oxides, Politics and Religion Journal (2018)
5. Design and Synthesis of Novel Quinazolinone-Pyrazole Derivatives As Potential Α-Glucosidase Inhibitors: Structure-Activity Relationship, Molecular Modeling and Kinetic Study, Bioorganic Chemistry (2021)
6. Design, Synthesis, Biological Evaluation, and Molecular Modeling Studies of Pyrazole-Benzofuran Hybrids As New Α-Glucosidase Inhibitor, Scientific Reports (2021)
7. Quinazolinone-Dihydropyrano[3,2-B]Pyran Hybrids As New Α-Glucosidase Inhibitors: Design, Synthesis, Enzymatic Inhibition, Docking Study and Prediction of Pharmacokinetic, Bioorganic Chemistry (2021)
8. Quercetin As a Promising Antiprotozoan Phytochemical: Current Knowledge and Future Research Avenues, BioMed Research International (2024)
9. Synthesis and Leishmanicidal Activity of 1-[5-(5-Nitrofuran-2-Yl)-1, 3, 4-Thiadiazole-2-Yl]-4-Benzoylepiperazines, Iranian Journal of Pharmaceutical Research (2017)
10. Synthesis, Molecular Docking Study, and Cytotoxic Activity of 1,3,5-Triaryl Pyrazole Derivatives, Letters in Drug Design and Discovery (2016)
11. Triarylpyrazole Derivatives As Potent Cytotoxic Agents; Synthesis and Bioactivity Evaluation Pyrazole Derivatives As Anticancer Agent, Drug Research (2021)
12. Design and Synthesis of New Imidazo[1,2-B]Pyrazole Derivatives, in Vitro Α-Glucosidase Inhibition, Kinetic and Docking Studies, Molecular Diversity (2020)
13. Synthesis, Characterization and Biological Evaluation of Novel 3-Methyl-5-Pyrazolone Derivatives, Journal of Medicinal and Chemical Sciences (2021)
14. Synthesis, in Vitro Α-Glucosidase Inhibitory Activity and Molecular Dynamics Simulation of Some New Coumarin-Fused 4H-Pyran Derivatives As Potential Anti-Diabetic Agents, Journal of Molecular Structure (2023)
15. Synthesis and Biological Evaluation of Chalcone-Triazole Hybrid Derivatives As 15-Lox Inhibitors, Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences (2018)
16. Synthesis of Novel Tacrine Analogs As Acetylcholinesterase Inhibitors, Journal of Heterocyclic Chemistry (2017)
17. Recent Advances in Design and Development of Diazole and Diazine Based Fungicides (2014-2023), Journal of Agricultural and Food Chemistry (2024)
18. Design and Synthesis of Bmh-21-Like Quinazolinone Derivatives As Potential Anti-Cancer Agents, Journal of Molecular Structure (2024)
19. Synthesis, in Vitro, and in Silico Studies of Newly Functionalized Quinazolinone Analogs for the Identification of Potent Α-Glucosidase Inhibitors, Journal of the Iranian Chemical Society (2021)
20. Synthesis of New Benzimidazole-1,2,3-Triazole Hybrids As Tyrosinase Inhibitors, Chemistry and Biodiversity (2018)