Tehran University of Medical Sciences

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Synthesis of a Carbon-14 Analog of 8-Chloro-11- (4-Methyl-1-Piperazinyl)-11-[14C]-5H-Dibenzo[B,E][1,4]Diazepine (Clozapine) Using Microwave Irradiation Publisher



Saadatjoo N1 ; Javaheri M1, 2 ; Saemian N2 ; Amini M3
Authors

Source: Radiochemistry Published:2016


Abstract

8-Chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine labeled with 14C in 11-position was synthesized in four steps from [carboxyl-14C]anthranilic acid using microwave irradiation with good overall radiochemical yield. © 2016, Pleiades Publishing, Inc.