Mitochondria in Immune Cells: Their Role in Immunity, Inflammation, and Metabolism Publisher



Athari SS ; Nasab EM ; Rajjoub RA ; Soor TAH ; Rashan L ; Borji M ; Changez M ; Hajimohammadi B ; Abdalla Y
Source: Mitochondrial Signaling and Regulation: Immune Responses and Diseases Published:2025

Abstract

Mitochondria, the powerhouses of the cell, have long been recognized for their crucial role in generating adenosine triphosphate through oxidative phosphorylation. However, over the past few decades, research has uncovered the far-reaching implications of mitochondrial function beyond energy production, particularly in immune cells. These organelles are central to processes such as immune cell activation, differentiation, signaling, and apoptosis. The link between mitochondrial function and immune responses has become a focal point in immunology, with growing recognition of how mitochondrial dysfunction contributes to the pathogenesis of various immune-related diseases © 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.