The Comparison of Plasma D-Dimer Levels in Benign and Malignant Tumors of Cervix, Ovary and Uterus



Dastjerdi MV^{2, 3, 4} ; Ahmari S^{2, 3, 4} ; Alipour S^{2, 3, 4} ; Tehranian A^{2, 3, 4}
Source: International Journal of Hematology-Oncology and Stem Cell Research Published:2015

Abstract

Background: Thromboembolism is the most important complication of cancers. The aim of this study was to determine D-dimer levels in benign and malignant tumors of the uterus, ovary and cervix. Subjects and Methods: This was a cross sectional study and it was conducted on 90 female patients referred to Imam Khomeini and Arash Hospitals because of uterine, cervical and ovarian tumors in 2013-2014. After surgical resection or tissue biopsy, 2 cc of each patient’s blood was taken to be sent to laboratory of hospitals. “Nycocard” kit was chosen to measure D-dimer levels in Mg/Lit by neflumetry method. Data were analyzed in SPSS-16 by T-test and One-Way ANOVA test. Results: The highest mean of D-dimer was 3.9 (± 2.9SD) in malignant cervical tumors. The mean plasma levels of D-dimer in malignant uterine cancers (P = 0.008), ovarian cancers (P = 0.007) and cervical cancers (P = 0.006) was significantly higher than benign tumors. In all three types of uterine, ovarian and cervical cancers, D-dimer was significantly higher in advanced stages than lower stages. Conclusion: The plasma D-dimer levels in patients with malignant tumors of the uterus, cervix and ovary were higher than benign types. By increasing the stage of gynecologic malignant tumors, the levels of plasma D-dimer were increased. © 2015, Tehran University of Medical Sciences (TUMS). All rights reserved.