Osmolarity: A Hidden Factor in Nanotoxicology Publisher Pubmed



Moayyedi S¹ ; Mashinchian O² ; Dinarvand R³
Source: DARU# Journal of Pharmaceutical Sciences Published:2016

Abstract

In the field of drug delivery, long circulating nanocarriers in the blood have many advantages such as targeted drug delivery and sustained release. Based on our current knowledge, evaluation of the effect of long circulating nanocarriers in the blood stream on osmolarity of plasma has not been reported before. In this study, osmotic pressure developed by some commercially available nanocarriers was estimated based on Van't Hoff equation. It is noteworthy that theoretically, nanocarriers do not have any significant effect on osmolarity of plasma. However, it is worth being evaluated experimentally in order to be taken into account in future studies. © 2016 Moayyedi et al.