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Detection of Occult Hepatitis B Virus in Patients Undergoing Chemotherapy in Iran Publisher



Shirmast P1 ; Shahri MA2 ; Pashangzadeh S3, 4 ; Mirshahabi H1 ; Samadi E1 ; Motamed N5
Authors

Source: Future Virology Published:2022


Abstract

Aim: Occult hepatitis B infection (OBI) is life threatening and has a high mortality rate despite applying antiviral treatments in cancer patients. This study aimed to investigate the prevalence of OBI in patients undergoing chemotherapy in Iran. Materials & methods: A total of 342 patients undergoing chemotherapy were enrolled. OBI detection in anti-HBc positive individuals was conducted using nested PCR. Results: Among 342 subjects, 103 (30.1%) were positive for anti-HBc. Fifteen (14.6%) cases of 103 anti-HBc positive samples were also positive for HBsAg. Overall, HBV DNA was positive in three (3.4%) of 88 anti-HBc subjects. Conclusion: Our results indicated that OBI might occur in almost one in 25 anti-HBc-positive patients undergoing chemotherapy. © 2021 Future Medicine Ltd.
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