Fabrication of Crosslinker-Free Chitosan-Hpmc Hydrogel for Implant Coating: A New Approach for the Treatment of Osteomyelitis

Fabrication of Crosslinker-Free Chitosan-Hpmc Hydrogel for Implant Coating: A New Approach for the Treatment of Osteomyelitis Publisher Pubmed

Zahraei M ; Aghazadeh E ; Dorkoosh FA ; Khalili Samani M ; Gholami M ; Abedishirehjin S ; Amin M ; Baeeri M ; Behrouzfar H ; Rezaei M ; Handali S

Source: Journal of Drug Targeting Published:2025

Abstract

The aim of this study was to fabricate a crosslinker free hydrogel coating composed of chitosan and HPMC (CH) containing gentamicin (GEM) as a promising strategy to prevent infections associated with orthopedic implants. The developed hydrogel exhibited good hemocompatibility, no cytotoxicity and the capability for long-term and slow release of GEM. In vivo study revealed that the WBC and NEUT values significantly reduced in rats treated with CH-GEM (WBC: 120%, NEUT: 131%) compared to those untreated and treated with CH alone (WBC: 172%, NEUT: 264%). According to X-ray findings, the group treated with CH-GEM exhibited slight periosteal reaction and screw loosening. Histological evaluation confirmed a significant reduction in inflammatory cells in the rats treated with CH-GEM compared to the other groups. The CFU counting results displayed a significant reduction in bacterial load on the bone, decreasing from 8.5 × 10⁸ CFU in the CH group to approximately 750 CFU in the CH-GEM group. Additionally, bacterial presence in the surrounding tissues was completely eradicated, with CFU counts dropping from approximately 3000 CFU to 0 CFU. The present findings revealed that CH-GEM coating might provide a promising platform for preventing post-operative osteomyelitis. © 2025 Informa UK Limited, trading as Taylor & Francis Group.

Style	Citing Format
MLA	Zahraei M, et al.. "Fabrication of Crosslinker-Free Chitosan-Hpmc Hydrogel for Implant Coating: A New Approach for the Treatment of Osteomyelitis." Journal of Drug Targeting, vol. , no. , 2025, pp. -.
APA	Zahraei M, Aghazadeh E, Dorkoosh FA, Khalili Samani M, Gholami M, Abedishirehjin S, Amin M, Baeeri M, Behrouzfar H, Rezaei M, Handali S (2025). Fabrication of Crosslinker-Free Chitosan-Hpmc Hydrogel for Implant Coating: A New Approach for the Treatment of Osteomyelitis. Journal of Drug Targeting, (), -.
Chicago	Zahraei M, Aghazadeh E, Dorkoosh FA, Khalili Samani M, Gholami M, Abedishirehjin S, Amin M, et al.. "Fabrication of Crosslinker-Free Chitosan-Hpmc Hydrogel for Implant Coating: A New Approach for the Treatment of Osteomyelitis." Journal of Drug Targeting , no. (2025): -.
Harvard	Zahraei M et al. (2025) 'Fabrication of Crosslinker-Free Chitosan-Hpmc Hydrogel for Implant Coating: A New Approach for the Treatment of Osteomyelitis', Journal of Drug Targeting, (), pp. -.
Vancouver	Zahraei M, Aghazadeh E, Dorkoosh FA, Khalili Samani M, Gholami M, Abedishirehjin S, et al.. Fabrication of Crosslinker-Free Chitosan-Hpmc Hydrogel for Implant Coating: A New Approach for the Treatment of Osteomyelitis. Journal of Drug Targeting. 2025;():-.
BibTex	@article{ author = {Zahraei M and Aghazadeh E and Dorkoosh FA and Khalili Samani M and Gholami M and Abedishirehjin S and Amin M and Baeeri M and Behrouzfar H and Rezaei M and Handali S}, title = {Fabrication of Crosslinker-Free Chitosan-Hpmc Hydrogel for Implant Coating: A New Approach for the Treatment of Osteomyelitis}, journal = {Journal of Drug Targeting}, volume = {}, number = {}, pages = {-}, year = {2025} }
RIS	TY - JOUR AU - Zahraei M AU - Aghazadeh E AU - Dorkoosh FA AU - Khalili Samani M AU - Gholami M AU - Abedishirehjin S AU - Amin M AU - Baeeri M AU - Behrouzfar H AU - Rezaei M AU - Handali S TI - Fabrication of Crosslinker-Free Chitosan-Hpmc Hydrogel for Implant Coating: A New Approach for the Treatment of Osteomyelitis JO - Journal of Drug Targeting VL - IS - SP - EP - PY - 2025 ER -

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