Impact of Bioactive Cements on Mineral Density of Artificially Demineralized Dentin Publisher

Summary: Can bioactive cements help in tooth remineralization? Research found all tested cements boosted mineral content in demineralized dentin, with Biodentine leading. #DentalResearch #ToothHealth

Nekoofar MH ; Kamangar SSH ; Valizadeh S ; Shahidi Z ; Dummer PMH
Source: European Journal of Prosthodontics and Restorative Dentistry Published:2025

Abstract

Objectives: Bioactive dental materials have the potential to remineralize carious dentin. This study compared the ability of four bioactive cements to increase the mineral content of demineralized dentin. Methods: Four cavities (2×0.5 mm) were prepared within the dentin of the occlusal surface of 15 teeth. The samples underwent pH-cycling for 14 days to induce demineralization. Three teeth were randomly assigned to each group (Biodentine, ACTIVA BioACTIVE, Oxford ActiveCal, Dycal, control). After placing the materials in the cavities, the entire occlusal surfaces were covered with composite resin, the samples were stored in a remineralizing solution for 30 days. The mineral density of the pulpal floors was determined using micro-CT. The data was analyzed with one-way ANOVA and Tukey tests. After horizontal sectioning, SEM-EDS mapping was done at the cementdentin interface of the cavity floor of one sample in each group. Results: There were significant differences between the test groups compared to the control group in terms of the mineral density of the cavity pulpal floors. The highest calcium and phosphorus weight percentages were observed in the Biodentine and ActiveCal groups, respectively. Conclusions: All the bioactive cements increased the mineral content of artificially demineralized dentin at the pulpal floor of the cavities. © 2025, Dennis Barber Ltd. All rights reserved.