Nicth With Secondary Acromegaloid Changes and Severe Hypoglycemia Due to Potentially Insulin-Like Growth Factor-2 Mediated Effects Publisher



Fatollahzadeh M ; Pajavand H ; Najafabadi MK ; Aghaei Meybodi HR
Source: Journal of Diabetes and Metabolic Disorders Published:2025

Abstract

Non-islet cell tumor hypoglycemia (NICTH) is a rare paraneoplastic syndrome resulting from excessive secretion of pro-insulin-like growth factor 2 (proIGF-2). This leads to hypoinsulinemic hypoglycemia and, in some cases, acromegaly. We report the case of a 52-year-old woman with NICTH syndrome who had decreased levels of insulin-like growth factor 1 (IGF1), insulin, C-peptide, and growth hormone (GH). The patient experienced severe hypoglycemia, with blood glucose levels dropping to 42 mg/dL (normal reference range; 70–100 mg/dL and SI unit; 2.33 mmol/L), resulting in tachycardia, palpitations, and confusion. Additionally, the patient exhibited acromegaloid features, such as a coarse facial appearance and hyperpigmentation. The patient presented with shortness of breath and chest pain. A mass was found in her left lung, which was successfully removed through thoracotomy surgery, resolving her hypoglycemic symptoms. © 2025 Elsevier B.V., All rights reserved.