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Investigation of Antitumor Effects of Lactobacillus Crispatus in Experimental Model of Breast Cancer in Balb/C Mice Publisher Pubmed



Motevaseli E1, 2 ; Khorramizadeh MR3, 4 ; Hadjati J5 ; Bonab SF5 ; Eslami S6 ; Ghafourifard S7
Authors

Source: Immunotherapy Published:2018


Abstract

Aim: To evaluate the effect of intraperitoneal injections of heat-killed Lactobacillus crispatus on breast tumor size and overall survival of Balb/c mouse received 4T1 mammary carcinoma. Materials and methods: Different doses of L. crispatus have been injected intraperitoneally in BALB/c mice. Results: Tumor size was decreased in the experiment group treated with 1 × 108 bacteria/200 μl. Treatment with 1 × 108 bacteria/200 μl resulted in survival improvement. The myeloid-derived suppressor cells and reactive oxygen species production have been increased in all groups. Cox2 expression decreased in tumor tissues of the mice treated with 108 bacteria/200 μl. The expressions of Arginase and iNos increased in the spleen and tumor tissues of those treated with 5 × 108 bacteria/200 μl. Conclusion: We have shown the protective effect of L. crispatus on survival of tumor-bearing mice. © 2018 2017 Future Medicine Ltd.
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