Global, Regional, and National Disease Burden Estimates of Acute Lower Respiratory Infections Due to Respiratory Syncytial Virus in Young Children in 2015: A Systematic Review and Modelling Study

Global, Regional, and National Disease Burden Estimates of Acute Lower Respiratory Infections Due to Respiratory Syncytial Virus in Young Children in 2015: A Systematic Review and Modelling Study Publisher Pubmed

Shi T¹ ; Mcallister DA² ; Obrien KL³ ; Simoes EAF⁴ ; Madhi SA^{5, 6} ; Gessner BD⁷ ; Polack FP⁸ ; Balsells E¹ ; Acacio S⁹ ; Aguayo C¹⁰ ; Alassani I¹¹ ; Ali A¹² ; Antonio M¹³ ; Awasthi S¹⁴ Show All Authors

Shi T¹
Mcallister DA²
Obrien KL³
Simoes EAF⁴
Madhi SA^{5, 6}
Gessner BD⁷
Polack FP⁸
Balsells E¹
Acacio S⁹
Aguayo C¹⁰
Alassani I¹¹
Ali A¹²
Antonio M¹³
Awasthi S¹⁴
Awori JO¹⁵
Azzizbaumgartner E^{16, 17}
Baggett HC^{18, 19}
Baillie VL⁵
Balmaseda A²⁰
Barahona A²¹
Basnet S^{22, 23}
Bassat Q^{9, 24, 25}
Basualdo W²⁶
Bigogo G²⁷
Bont L²⁸
Breiman RF²⁹
Brooks WA^{3, 16}
Broor S³⁰
Bruce N³¹
Bruden D³²
Buchy P^{33, 34}
Campbell S¹
Carosonelink P³⁵
Chadha M³⁶
Chipeta J³⁷
Chou M³⁸
Clara W³⁹
Cohen C^{40, 41}
De Cuellar E⁴²
Dang DA⁴³
Dashyandag B⁴⁴
Deloriaknoll M³
Dherani M³¹
Eap T⁴⁵
Ebruke BE¹³
Echavarria M⁴⁶
De Freitas Lazaro Emediato CC⁴⁷
Fasce RA⁴⁸
Feikin DR¹⁷
Feng L⁴⁹
Gentile A⁵⁰
Gordon A⁵¹
Goswami D^{3, 16}
Goyet S³³
Groome M^{5, 6}
Halasa N⁵²
Hirve S⁵³
Homaira N^{16, 54}
Howie SRC^{13, 55, 56}
Jara J⁵⁷
Jroundi I^{24, 58}
Kartasasmita CB⁵⁹
Khuribulos N⁶⁰
Kotloff KL⁶¹
Krishnan A³⁰
Libster R^{8, 52, 62}
Lopez O⁶³
Lucero MG⁶⁴
Lucion F⁵⁰
Lupisan SP⁶⁵
Marcone DN⁴⁶
Mccracken JP⁵⁷
Mejia M⁶⁶
Moisi JC⁷
Montgomery JM⁶⁷
Moore DP^{5, 6}
Moraleda C²⁴
Moyes J^{40, 41}
Munywoki P^{15, 68}
Mutyara K⁵⁹
Nicol MP⁶⁹
Nokes DJ^{15, 70}
Nymadawa P⁷¹
Da Costa Oliveira MT⁴⁷
Oshitani H⁷²
Pandey N¹⁴
Paranhosbaccala G⁷³
Phillips LN⁷⁴
Picot VS⁷³
Rahman M¹⁶
Rakotoandrianarivelo M⁷⁵
Rasmussen ZA⁷⁶
Rath BA⁷⁷
Robinson A⁷⁸
Romero C⁷⁹
Russomando G⁸⁰
Salimi V⁸¹
Sawatwong P¹⁸
Scheltema N²⁸
Schweiger B⁸²
Scott JAG^{15, 83}
Seidenberg P⁸⁴
Shen K⁸⁵
Singleton R^{32, 86}
Sotomayor V¹⁰
Strand TA^{22, 87}
Sutanto A⁸⁸
Sylla M⁸⁹
Tapia MD⁶¹
Thamthitiwat S¹⁸
Thomas ED⁷⁶
Tokarz R⁹⁰
Turner C⁹¹
Venter M⁹²
Waicharoen S⁹³
Wang J⁹⁴
Watthanaworawit W⁹¹
Yoshida LM⁹⁵
Yu H⁴⁹
Zar HJ⁹⁶
Campbell H¹
Nair H^{1, 97}

Source: The Lancet Published:2017

Abstract

Background We have previously estimated that respiratory syncytial virus (RSV) was associated with 22% of all episodes of (severe) acute lower respiratory infection (ALRI) resulting in 55 000 to 199 000 deaths in children younger than 5 years in 2005. In the past 5 years, major research activity on RSV has yielded substantial new data from developing countries. With a considerably expanded dataset from a large international collaboration, we aimed to estimate the global incidence, hospital admission rate, and mortality from RSV-ALRI episodes in young children in 2015. Methods We estimated the incidence and hospital admission rate of RSV-associated ALRI (RSV-ALRI) in children younger than 5 years stratified by age and World Bank income regions from a systematic review of studies published between Jan 1, 1995, and Dec 31, 2016, and unpublished data from 76 high quality population-based studies. We estimated the RSV-ALRI incidence for 132 developing countries using a risk factor-based model and 2015 population estimates. We estimated the in-hospital RSV-ALRI mortality by combining in-hospital case fatality ratios with hospital admission estimates from hospital-based (published and unpublished) studies. We also estimated overall RSV-ALRI mortality by identifying studies reporting monthly data for ALRI mortality in the community and RSV activity. Findings We estimated that globally in 2015, 33·1 million (uncertainty range [UR] 21·6–50·3) episodes of RSV-ALRI, resulted in about 3·2 million (2·7–3·8) hospital admissions, and 59 600 (48 000–74 500) in-hospital deaths in children younger than 5 years. In children younger than 6 months, 1·4 million (UR 1·2–1·7) hospital admissions, and 27 300 (UR 20 700–36 200) in-hospital deaths were due to RSV-ALRI. We also estimated that the overall RSV-ALRI mortality could be as high as 118 200 (UR 94 600–149 400). Incidence and mortality varied substantially from year to year in any given population. Interpretation Globally, RSV is a common cause of childhood ALRI and a major cause of hospital admissions in young children, resulting in a substantial burden on health-care services. About 45% of hospital admissions and in-hospital deaths due to RSV-ALRI occur in children younger than 6 months. An effective maternal RSV vaccine or monoclonal antibody could have a substantial effect on disease burden in this age group. Funding The Bill & Melinda Gates Foundation. © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license

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Style	Citing Format
MLA	Shi T, et al.. "Global, Regional, and National Disease Burden Estimates of Acute Lower Respiratory Infections Due to Respiratory Syncytial Virus in Young Children in 2015: A Systematic Review and Modelling Study." The Lancet, vol. 390, no. 10098, 2017, pp. 946-958.
APA	Shi T, Mcallister DA, Obrien KL, Simoes EAF, Madhi SA, Gessner BD, Polack FP, Balsells E, Acacio S, Aguayo C, Alassani I, Ali A, Antonio M, Awasthi S, Awori JO, Azzizbaumgartner E, Baggett HC, Baillie VL, Balmaseda A, ... Nair H (2017). Global, Regional, and National Disease Burden Estimates of Acute Lower Respiratory Infections Due to Respiratory Syncytial Virus in Young Children in 2015: A Systematic Review and Modelling Study. The Lancet, 390(10098), 946-958.
Chicago	Shi T, Mcallister DA, Obrien KL, Simoes EAF, Madhi SA, Gessner BD, Polack FP, et al.. "Global, Regional, and National Disease Burden Estimates of Acute Lower Respiratory Infections Due to Respiratory Syncytial Virus in Young Children in 2015: A Systematic Review and Modelling Study." The Lancet 390, no. 10098 (2017): 946-958.
Harvard	Shi T et al. (2017) 'Global, Regional, and National Disease Burden Estimates of Acute Lower Respiratory Infections Due to Respiratory Syncytial Virus in Young Children in 2015: A Systematic Review and Modelling Study', The Lancet, 390(10098), pp. 946-958.
Vancouver	Shi T, Mcallister DA, Obrien KL, Simoes EAF, Madhi SA, Gessner BD, et al.. Global, Regional, and National Disease Burden Estimates of Acute Lower Respiratory Infections Due to Respiratory Syncytial Virus in Young Children in 2015: A Systematic Review and Modelling Study. The Lancet. 2017;390(10098):946-958.
BibTex	@article{ author = {Shi T and Mcallister DA and Obrien KL and Simoes EAF and Madhi SA and Gessner BD and Polack FP and Balsells E and Acacio S and Aguayo C and Alassani I and Ali A and Antonio M and Awasthi S and Awori JO and Azzizbaumgartner E and Baggett HC and Baillie VL and Balmaseda A and Barahona A and Basnet S and Bassat Q and Basualdo W and Bigogo G and Bont L and Breiman RF and Brooks WA and Broor S and Bruce N and Bruden D and Buchy P and Campbell S and Carosonelink P and Chadha M and Chipeta J and Chou M and Clara W and Cohen C and De Cuellar E and Dang DA and Dashyandag B and Deloriaknoll M and Dherani M and Eap T and Ebruke BE and Echavarria M and De Freitas Lazaro Emediato CC and Fasce RA and Feikin DR and Feng L and Gentile A and Gordon A and Goswami D and Goyet S and Groome M and Halasa N and Hirve S and Homaira N and Howie SRC and Jara J and Jroundi I and Kartasasmita CB and Khuribulos N and Kotloff KL and Krishnan A and Libster R and Lopez O and Lucero MG and Lucion F and Lupisan SP and Marcone DN and Mccracken JP and Mejia M and Moisi JC and Montgomery JM and Moore DP and Moraleda C and Moyes J and Munywoki P and Mutyara K and Nicol MP and Nokes DJ and Nymadawa P and Da Costa Oliveira MT and Oshitani H and Pandey N and Paranhosbaccala G and Phillips LN and Picot VS and Rahman M and Rakotoandrianarivelo M and Rasmussen ZA and Rath BA and Robinson A and Romero C and Russomando G and Salimi V and Sawatwong P and Scheltema N and Schweiger B and Scott JAG and Seidenberg P and Shen K and Singleton R and Sotomayor V and Strand TA and Sutanto A and Sylla M and Tapia MD and Thamthitiwat S and Thomas ED and Tokarz R and Turner C and Venter M and Waicharoen S and Wang J and Watthanaworawit W and Yoshida LM and Yu H and Zar HJ and Campbell H and Nair H}, title = {Global, Regional, and National Disease Burden Estimates of Acute Lower Respiratory Infections Due to Respiratory Syncytial Virus in Young Children in 2015: A Systematic Review and Modelling Study}, journal = {The Lancet}, volume = {390}, number = {10098}, pages = {946-958}, year = {2017} }
RIS	TY - JOUR AU - Shi T AU - Mcallister DA AU - Obrien KL AU - Simoes EAF AU - Madhi SA AU - Gessner BD AU - Polack FP AU - Balsells E AU - Acacio S AU - Aguayo C AU - Alassani I AU - Ali A AU - Antonio M AU - Awasthi S AU - Awori JO AU - Azzizbaumgartner E AU - Baggett HC AU - Baillie VL AU - Balmaseda A AU - Barahona A AU - Basnet S AU - Bassat Q AU - Basualdo W AU - Bigogo G AU - Bont L AU - Breiman RF AU - Brooks WA AU - Broor S AU - Bruce N AU - Bruden D AU - Buchy P AU - Campbell S AU - Carosonelink P AU - Chadha M AU - Chipeta J AU - Chou M AU - Clara W AU - Cohen C AU - De Cuellar E AU - Dang DA AU - Dashyandag B AU - Deloriaknoll M AU - Dherani M AU - Eap T AU - Ebruke BE AU - Echavarria M AU - De Freitas Lazaro Emediato CC AU - Fasce RA AU - Feikin DR AU - Feng L AU - Gentile A AU - Gordon A AU - Goswami D AU - Goyet S AU - Groome M AU - Halasa N AU - Hirve S AU - Homaira N AU - Howie SRC AU - Jara J AU - Jroundi I AU - Kartasasmita CB AU - Khuribulos N AU - Kotloff KL AU - Krishnan A AU - Libster R AU - Lopez O AU - Lucero MG AU - Lucion F AU - Lupisan SP AU - Marcone DN AU - Mccracken JP AU - Mejia M AU - Moisi JC AU - Montgomery JM AU - Moore DP AU - Moraleda C AU - Moyes J AU - Munywoki P AU - Mutyara K AU - Nicol MP AU - Nokes DJ AU - Nymadawa P AU - Da Costa Oliveira MT AU - Oshitani H AU - Pandey N AU - Paranhosbaccala G AU - Phillips LN AU - Picot VS AU - Rahman M AU - Rakotoandrianarivelo M AU - Rasmussen ZA AU - Rath BA AU - Robinson A AU - Romero C AU - Russomando G AU - Salimi V AU - Sawatwong P AU - Scheltema N AU - Schweiger B AU - Scott JAG AU - Seidenberg P AU - Shen K AU - Singleton R AU - Sotomayor V AU - Strand TA AU - Sutanto A AU - Sylla M AU - Tapia MD AU - Thamthitiwat S AU - Thomas ED AU - Tokarz R AU - Turner C AU - Venter M AU - Waicharoen S AU - Wang J AU - Watthanaworawit W AU - Yoshida LM AU - Yu H AU - Zar HJ AU - Campbell H AU - Nair H TI - Global, Regional, and National Disease Burden Estimates of Acute Lower Respiratory Infections Due to Respiratory Syncytial Virus in Young Children in 2015: A Systematic Review and Modelling Study JO - The Lancet VL - 390 IS - 10098 SP - 946 EP - 958 PY - 2017 ER -

Style

Citing Format

MLA

Shi T, et al.. "Global, Regional, and National Disease Burden Estimates of Acute Lower Respiratory Infections Due to Respiratory Syncytial Virus in Young Children in 2015: A Systematic Review and Modelling Study." The Lancet, vol. 390, no. 10098, 2017, pp. 946-958.

APA

Shi T, Mcallister DA, Obrien KL, Simoes EAF, Madhi SA, Gessner BD, Polack FP, Balsells E, Acacio S, Aguayo C, Alassani I, Ali A, Antonio M, Awasthi S, Awori JO, Azzizbaumgartner E, Baggett HC, Baillie VL, Balmaseda A, ... Nair H (2017). Global, Regional, and National Disease Burden Estimates of Acute Lower Respiratory Infections Due to Respiratory Syncytial Virus in Young Children in 2015: A Systematic Review and Modelling Study. The Lancet, 390(10098), 946-958.

Chicago

Shi T, Mcallister DA, Obrien KL, Simoes EAF, Madhi SA, Gessner BD, Polack FP, et al.. "Global, Regional, and National Disease Burden Estimates of Acute Lower Respiratory Infections Due to Respiratory Syncytial Virus in Young Children in 2015: A Systematic Review and Modelling Study." The Lancet 390, no. 10098 (2017): 946-958.

Harvard

Shi T et al. (2017) 'Global, Regional, and National Disease Burden Estimates of Acute Lower Respiratory Infections Due to Respiratory Syncytial Virus in Young Children in 2015: A Systematic Review and Modelling Study', The Lancet, 390(10098), pp. 946-958.

Vancouver

Shi T, Mcallister DA, Obrien KL, Simoes EAF, Madhi SA, Gessner BD, et al.. Global, Regional, and National Disease Burden Estimates of Acute Lower Respiratory Infections Due to Respiratory Syncytial Virus in Young Children in 2015: A Systematic Review and Modelling Study. The Lancet. 2017;390(10098):946-958.

BibTex

@article{ author = {Shi T and Mcallister DA and Obrien KL and Simoes EAF and Madhi SA and Gessner BD and Polack FP and Balsells E and Acacio S and Aguayo C and Alassani I and Ali A and Antonio M and Awasthi S and Awori JO and Azzizbaumgartner E and Baggett HC and Baillie VL and Balmaseda A and Barahona A and Basnet S and Bassat Q and Basualdo W and Bigogo G and Bont L and Breiman RF and Brooks WA and Broor S and Bruce N and Bruden D and Buchy P and Campbell S and Carosonelink P and Chadha M and Chipeta J and Chou M and Clara W and Cohen C and De Cuellar E and Dang DA and Dashyandag B and Deloriaknoll M and Dherani M and Eap T and Ebruke BE and Echavarria M and De Freitas Lazaro Emediato CC and Fasce RA and Feikin DR and Feng L and Gentile A and Gordon A and Goswami D and Goyet S and Groome M and Halasa N and Hirve S and Homaira N and Howie SRC and Jara J and Jroundi I and Kartasasmita CB and Khuribulos N and Kotloff KL and Krishnan A and Libster R and Lopez O and Lucero MG and Lucion F and Lupisan SP and Marcone DN and Mccracken JP and Mejia M and Moisi JC and Montgomery JM and Moore DP and Moraleda C and Moyes J and Munywoki P and Mutyara K and Nicol MP and Nokes DJ and Nymadawa P and Da Costa Oliveira MT and Oshitani H and Pandey N and Paranhosbaccala G and Phillips LN and Picot VS and Rahman M and Rakotoandrianarivelo M and Rasmussen ZA and Rath BA and Robinson A and Romero C and Russomando G and Salimi V and Sawatwong P and Scheltema N and Schweiger B and Scott JAG and Seidenberg P and Shen K and Singleton R and Sotomayor V and Strand TA and Sutanto A and Sylla M and Tapia MD and Thamthitiwat S and Thomas ED and Tokarz R and Turner C and Venter M and Waicharoen S and Wang J and Watthanaworawit W and Yoshida LM and Yu H and Zar HJ and Campbell H and Nair H}, title = {Global, Regional, and National Disease Burden Estimates of Acute Lower Respiratory Infections Due to Respiratory Syncytial Virus in Young Children in 2015: A Systematic Review and Modelling Study}, journal = {The Lancet}, volume = {390}, number = {10098}, pages = {946-958}, year = {2017} }

RIS

TY - JOUR
AU - Shi T
AU - Mcallister DA
AU - Obrien KL
AU - Simoes EAF
AU - Madhi SA
AU - Gessner BD
AU - Polack FP
AU - Balsells E
AU - Acacio S
AU - Aguayo C
AU - Alassani I
AU - Ali A
AU - Antonio M
AU - Awasthi S
AU - Awori JO
AU - Azzizbaumgartner E
AU - Baggett HC
AU - Baillie VL
AU - Balmaseda A
AU - Barahona A
AU - Basnet S
AU - Bassat Q
AU - Basualdo W
AU - Bigogo G
AU - Bont L
AU - Breiman RF
AU - Brooks WA
AU - Broor S
AU - Bruce N
AU - Bruden D
AU - Buchy P
AU - Campbell S
AU - Carosonelink P
AU - Chadha M
AU - Chipeta J
AU - Chou M
AU - Clara W
AU - Cohen C
AU - De Cuellar E
AU - Dang DA
AU - Dashyandag B
AU - Deloriaknoll M
AU - Dherani M
AU - Eap T
AU - Ebruke BE
AU - Echavarria M
AU - De Freitas Lazaro Emediato CC
AU - Fasce RA
AU - Feikin DR
AU - Feng L
AU - Gentile A
AU - Gordon A
AU - Goswami D
AU - Goyet S
AU - Groome M
AU - Halasa N
AU - Hirve S
AU - Homaira N
AU - Howie SRC
AU - Jara J
AU - Jroundi I
AU - Kartasasmita CB
AU - Khuribulos N
AU - Kotloff KL
AU - Krishnan A
AU - Libster R
AU - Lopez O
AU - Lucero MG
AU - Lucion F
AU - Lupisan SP
AU - Marcone DN
AU - Mccracken JP
AU - Mejia M
AU - Moisi JC
AU - Montgomery JM
AU - Moore DP
AU - Moraleda C
AU - Moyes J
AU - Munywoki P
AU - Mutyara K
AU - Nicol MP
AU - Nokes DJ
AU - Nymadawa P
AU - Da Costa Oliveira MT
AU - Oshitani H
AU - Pandey N
AU - Paranhosbaccala G
AU - Phillips LN
AU - Picot VS
AU - Rahman M
AU - Rakotoandrianarivelo M
AU - Rasmussen ZA
AU - Rath BA
AU - Robinson A
AU - Romero C
AU - Russomando G
AU - Salimi V
AU - Sawatwong P
AU - Scheltema N
AU - Schweiger B
AU - Scott JAG
AU - Seidenberg P
AU - Shen K
AU - Singleton R
AU - Sotomayor V
AU - Strand TA
AU - Sutanto A
AU - Sylla M
AU - Tapia MD
AU - Thamthitiwat S
AU - Thomas ED
AU - Tokarz R
AU - Turner C
AU - Venter M
AU - Waicharoen S
AU - Wang J
AU - Watthanaworawit W
AU - Yoshida LM
AU - Yu H
AU - Zar HJ
AU - Campbell H
AU - Nair H
TI - Global, Regional, and National Disease Burden Estimates of Acute Lower Respiratory Infections Due to Respiratory Syncytial Virus in Young Children in 2015: A Systematic Review and Modelling Study
JO - The Lancet
VL - 390
IS - 10098
SP - 946
EP - 958
PY - 2017
ER -

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