Assessment of Dietary Intake and Its Inflammatory Potential in Persons With Pediatric-Onset Multiple Sclerosis Publisher Pubmed



Bitarafan S^{1, 2} ; Zhu F¹ ; Mirza A¹ ; Bernstein CN³ ; Van Domselaar G^{5, 6} ; Marrie RA⁴ ; Yeh EA⁷ ; Zhao Y¹ ; Banwell B⁸ ; Waubant E⁹ ; Tremlett H¹
Source: Multiple Sclerosis and Related Disorders Published:2024

Abstract

Objective: To compare diet and the modified dietary inflammatory index (mDII) between individuals with pediatric-onset multiple sclerosis (PoMS), monophasic acquired demyelinating syndromes (monoADS), and controls. Methods: The association between diet, mDII, and disease status was examined in 131 individuals with PoMS/monoADS/controls (38/45/48) using logistic regression. Results: The associations between diet and PoMS were modest, reaching significance for whole grain intake (adjusted odds ratio, aOR=0.964, 95 % confidence intervals, CI:0.934–0.995) but not mDII (aOR=1.20, 95 %CI:0.995–1.46) versus controls. No findings for monoADS reached significance versus controls. Conclusions: Individuals with PoMS, but not monoADS, had lower dietary whole grain intake than controls. © 2024 The Author(s)