Combination Therapy: Cancer Vaccines and Other Therapeutics Publisher



Keshavarzfathi M^{1, 2, 3} ; Rezaei N^{3, 4, 5}
Source: Vaccines for Cancer Immunotherapy: An Evidence-Based Review on Current Status and Future Perspectives Published:2018

Abstract

The efficacy of cancer vaccines as a monotherapy may be undervalued because of immunosuppression and immune regulatory functions. Combining vaccines with other therapeutics can overcome these barriers and enhance the efficacy of cancer vaccines. Cancer vaccines have been combined with other therapeutics such as chemotherapy, radiation therapy, and small molecule inhibitors, as well as immunotherapy such as cytokines, immune checkpoint inhibitors, and tumor targeted monoclonal antibodies. These combinations have been evaluated in many preclinical and clinical studies. Here, we will review these combination therapies and their potential for improving the efficacy of vaccines. © 2019 Nima Rezaei and Mahsa Keshavarz-Fathi Published by Elsevier Ltd All rights reserved.