Statin-Induced Nitric Oxide Signaling: Mechanisms and Therapeutic Implications Publisher



Gorabi AM¹ ; Kiaie N¹ ; Hajighasemi S² ; Banach M^{3, 4} ; Penson PE⁵ ; Jamialahmadi T^{6, 7} ; Sahebkar A^{8, 9, 10}
Source: Journal of Clinical Medicine Published:2019

Abstract

In addition to their cholesterol-lowering effects, statins are associated with pleiotropic effects including improvements in heart failure (HF), reduced blood pressure, prevention of the rupture of atherosclerotic plaques and improved angiogenesis. In addition to these cardiovascular benefits, statins have been implicated in the treatment of neurological injuries, cancer, sepsis, and cirrhosis. These cholesterol-independent beneficial effects of statins are predominantly mediated through signaling pathways leading to increased production and bioavailability of nitric oxide (NO). In this review, the mechanistic pathways and therapeutic effects of statin-mediated elevations of NO are described and discussed. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.