Introducing a Noninvasive, Non-Surgical, and Reversible Animal Model for Fecal Incontinence Using Abobotulinumtoxina in Dogs

Introducing a Noninvasive, Non-Surgical, and Reversible Animal Model for Fecal Incontinence Using Abobotulinumtoxina in Dogs Publisher

Bangash MY¹ ; Pedram MS¹ ; Mehrabi V² ; Dehghan MM¹ ; Mansoori K³ ; Soroori S¹ ; Banifazl S⁴ ; Dadgar F⁵ ; Dezfouli MRM⁶

Source: Veterinary Research Forum Published:2022

Abstract

The aim of this study was to introduce a new animal model of fecal incontinence (FI) by injecting abobotulinumtoxinA in the external anal sphincter (EAS) muscle of dogs which replaces models based on anal sphincter destructions that are invasive, mostly require surgical procedures, expensive, permanent, and painful to the animals. 4 healthy mongrel dogs were used in this study. First, they were received NaCl 0.09% (as control) injections in EAS muscle and effects were assessed by means of Electromyography (EMG) and clinically evaluated by sphincter pinch test and presence of leakage of feces for 2 weeks. Then, they received abobotulinumtoxinA in EAS muscle and reevaluated for 6 weeks to see short-term and medium-term effects of abobotulinumtoxinA injection. Saline had no significant changes in results obtained from EMG, however, there were significant decreases in amplitudes of action potentials after receiving abobotulinumtoxinA in comparison with no injection or saline injection in EAS muscle. Pinch tests were normal after saline injection assessment period, however, then started to be negative, ranging from two days after abobotulinumtoxinA injection to seven days after receiving abobotulinumtoxinA. Animals also had significant presentations of fecal incontinence (leakage of feces and cage contamination with feces) from the 1st week after receiving abobotulinumtoxinA until the 6th week after receiving abobotulinumtoxinA. AbobotulinumtoxinA caused paralysis in the EAS and producd FI conditions in dogs. This animal model was an appropriate substitute to the various invasive, expensive and also complicated procedures with an easy, feasible, noninvasive and non-painful single-stage abobotulinumtoxinA injection. © 2022 Urmia University. All rights reserved.

2. Partial Lateral Internal Sphincterotomy Versus Combined Botulinum Toxin a Injection and Topical Diltiazem in the Treatment of Chronic Anal Fissure: A Randomized Clinical Trial, Diseases of the Colon and Rectum (2015)

3. L-Arginine Is a Feasible Supplement to Heal Chronic Anal Fissure Via Reducing Internal Anal Sphincter Pressure: A Randomized Clinical Trial Study, Amino Acids (2023)

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Hossein Gandomkar (1)

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Style	Citing Format
MLA	Bangash MY, et al.. "Introducing a Noninvasive, Non-Surgical, and Reversible Animal Model for Fecal Incontinence Using Abobotulinumtoxina in Dogs." Veterinary Research Forum, vol. 13, no. 2, 2022, pp. 215-221.
APA	Bangash MY, Pedram MS, Mehrabi V, Dehghan MM, Mansoori K, Soroori S, Banifazl S, Dadgar F, Dezfouli MRM (2022). Introducing a Noninvasive, Non-Surgical, and Reversible Animal Model for Fecal Incontinence Using Abobotulinumtoxina in Dogs. Veterinary Research Forum, 13(2), 215-221.
Chicago	Bangash MY, Pedram MS, Mehrabi V, Dehghan MM, Mansoori K, Soroori S, Banifazl S, Dadgar F, Dezfouli MRM. "Introducing a Noninvasive, Non-Surgical, and Reversible Animal Model for Fecal Incontinence Using Abobotulinumtoxina in Dogs." Veterinary Research Forum 13, no. 2 (2022): 215-221.
Harvard	Bangash MY et al. (2022) 'Introducing a Noninvasive, Non-Surgical, and Reversible Animal Model for Fecal Incontinence Using Abobotulinumtoxina in Dogs', Veterinary Research Forum, 13(2), pp. 215-221.
Vancouver	Bangash MY, Pedram MS, Mehrabi V, Dehghan MM, Mansoori K, Soroori S, et al.. Introducing a Noninvasive, Non-Surgical, and Reversible Animal Model for Fecal Incontinence Using Abobotulinumtoxina in Dogs. Veterinary Research Forum. 2022;13(2):215-221.
BibTex	@article{ author = {Bangash MY and Pedram MS and Mehrabi V and Dehghan MM and Mansoori K and Soroori S and Banifazl S and Dadgar F and Dezfouli MRM}, title = {Introducing a Noninvasive, Non-Surgical, and Reversible Animal Model for Fecal Incontinence Using Abobotulinumtoxina in Dogs}, journal = {Veterinary Research Forum}, volume = {13}, number = {2}, pages = {215-221}, year = {2022} }
RIS	TY - JOUR AU - Bangash MY AU - Pedram MS AU - Mehrabi V AU - Dehghan MM AU - Mansoori K AU - Soroori S AU - Banifazl S AU - Dadgar F AU - Dezfouli MRM TI - Introducing a Noninvasive, Non-Surgical, and Reversible Animal Model for Fecal Incontinence Using Abobotulinumtoxina in Dogs JO - Veterinary Research Forum VL - 13 IS - 2 SP - 215 EP - 221 PY - 2022 ER -

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