Effect of a Short-Term Lifestyle Modification Program on Quality of Life, Anthropometric Characteristics and Cd4+T Cell Count of Hiv Infected Patients in Tehran/Iran: A Randomized Controlled Trial Publisher Pubmed



Ghayomzadeh M¹ ; Etesami MS² ; Earnest CP³ ; Rezaei S¹ ; Navalta JW⁴ ; Taj L⁵ ; Seyedalinaghi S⁵ ; Mohraz M⁵ ; Gharakhanlou R¹ ; Voltarelli FA⁶
Source: Explore Published:2019

Abstract

Context: Increasing physical activity and promoting healthy behaviors may play a key role in reducing the adverse effects of antiretroviral therapy and HIV. Objective: This study investigated the effects of an 8-week lifestyle modification program (LMP) on quality of life, anthropometric characteristics and CD4+T cell count of people living with HIV (PLWH). Methods: Thirty PLWH taking ART were randomly assigned to a lifestyle modification program (LMP) (n = 15) or standard care control (CON) group (n = 15). All volunteers underwent body composition, CD4+T cell count measurement and quality of life assessments at the beginning and end of a two-month experimental period. Results: At follow-up, we observed a significant increase in CD4+T cell count (117.52 cells/mm3; 95% CI, 36.59–198.45) and all subscales and total quality of life score (Short-Form 36 (SF-36) in the LMP group. While we did not observe a significant change in body composition for the LMP group, we did observe a significant increase in body fat (1.75%; 95% CI, 0.15, 2.33) and a reduction in lean body mass (−1.26; 95% CI, −1.26, −2.39) for the CON group. Conclusion: A LMP can be safely used as an effective intervention for improving quality of life and immune competence of PLWH who lack time to participate in a structured exercise regimen. Trial registration: IRCT 201604034076N18. Registered: 2016-05-05.web address of TRIAL: en.search.irct.ir/trial/4262 © 2019 Elsevier Inc.