A Novel Therapeutic Strategy for Parkinson's Disease Based on the Gut Microbiota: A Rreview Article



R Kardan ROMINA ; M Nazari MOHSEN ; M Ashab MAHTAB ; J Hemmati JABER ; A Ahmadi AMJAD
Source: Scientific Journal of Kurdistan University of Medical Sciences Published:2024

Abstract

Background and Aim:The gut microbiota, which is now recognized as an important organ of the human body, can have an impact on various neurological outcomes such as cognition, learning, and memory. The aim of this study was to investigate the relationship between gut microbiota and Parkinson's disease and also to highlight appropriate microbiota-based therapeutic approaches for Parkinson's disease Materials and Methods: In this study, we searched and extracted the articles based on the keywords of Parkinson's, gut microbiota, gut microbiome, fecal microbiota, fecal microbiome, probiotic, and gut-brain axis from all data bases. Our inclusion criteria included English and Persian language articles, original articles and articles with open access, and the exclusion criteria of the study included articles other than English and Persian articles, articles without open access, meta-analysis and review articles. Finally, 38 articles were reviewed and analyzed. Results: Fecal microbiota transplant and probiotics laid the groundwork for identifying the mechanisms underlying the ability of the gut microbiota to influence a host's brain and behavior. It could help in prevention or early diagnosis of Parkinson's disease possibly through some peripheral biomarkers. Conclusion: Recent studies have also shown that patients with Parkinson's disease have a disruption in gut microbiota balance (dysbiosis), but its exact role in causing the neurological disorder is still unknown. However, new approaches based on gut microbiota can be developed to prevent and treat neurological disorders such as Parkinson's disease. © 2024 Elsevier B.V., All rights reserved.