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Granuloma Annulare After Botulonium Toxin a Injection: A Rare Association Publisher Pubmed



Balighi K1 ; Kamyab K2 ; Azizpour A1
Authors

Source: Journal of Cosmetic Dermatology Published:2020


Abstract

Background: Botulinum toxin is generally considered safe and has been used in constantly expanded cosmetic and therapeutic indications. However, long-term side effects such as granulomatous reactions have been associated with this drug. Aims: We aim to evaluate a rare reaction to Botulonium toxin A injection. Patients/Methods: A 44-year-old woman, developed annular plaques eleven months after botulinum toxin A injection for the correction treatment of wrinklesglabellar rhytides. Results: Histopathological examination revealed granuloma annulare formation. Clinical and biological investigations were negative, ruling out the hypothesis of systemic sarcoidosis. Triamcinolone acetonide injection was followed by a regression of the plaques. Conclusion: There are previous reports in the literature of sarcoidal and foreign body granuloma at the sites of injection of botulinum toxin A injection. To our knowledge this is the first report of granuloma annulare occurrence after botulinum toxin A injection. © 2020 Wiley Periodicals, Inc.
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