Effective Materials of Medicinal Plants for Leishmania Treatment in Vivo Environment Publisher



Mehrizi TZ¹ ; Hamedani MP² ; Shahmabadi HE³ ; Mirzaei M⁴ ; Ardestani MS⁵ ; Hoseini MHM⁶ ; Mosaffa N⁶ ; Khamesipour A⁷ ; Javanmard A⁸ ; Rezazadeh S⁹ ; Ramezani A¹
Source: Journal of Medicinal Plants Published:2020

Abstract

Background: Treatment of leishmaniasis is a challenge due to problems such as high price and dose of the drug, drug resistance and side effects. Objective: The study aims to introduce plants compounds, which their antileishmanial effects were approved in vivo conditions. Methods: This study as a review article was performed by searching the keywords of medicinal plants with in vivo antileishmanial effects, nanocarrier, clinical trials, and mechanism of action in the well-known databases to 2018. In this study, 14 medicinal plant compounds with antileishmanial effects were reviewed and mechanism of action and their in vivo therapeutic effect were evaluated. Results: It was found that while some of these compounds had low antileishmanial effects, their efficacy against leishmaniasis was significantly increased through loading into nanocarriers. Conclusion: This study indicated that active component of medicinal plants especially along with nano carriers can be of interest for the treatment of Leishmania. © 2020 Institute of Medicinal Plants. All rights reserved.