Preliminary Data Revealing Efficacy of Streptococcus Salivarius K12 (Ssk12) in Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (Pfapa) Syndrome: A Multicenter Study From the Aida Network Pfapa Syndrome Registry

Preliminary Data Revealing Efficacy of Streptococcus Salivarius K12 (Ssk12) in Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (Pfapa) Syndrome: A Multicenter Study From the Aida Network Pfapa Syndrome Registry Publisher

La Torre F¹ ; Sota J² ; Insalaco A³ ; Conti G⁴ ; Del Giudice E⁵ ; Lubrano R⁵ ; Breda L⁶ ; Maggio MC⁷ ; Civino A⁸ ; Mastrorilli V¹ ; Loconte R¹ ; Natale MF³ ; Celani C³ ; Romeo M⁴ Show All Authors

La Torre F¹
Sota J²
Insalaco A³
Conti G⁴
Del Giudice E⁵
Lubrano R⁵
Breda L⁶
Maggio MC⁷
Civino A⁸
Mastrorilli V¹
Loconte R¹
Natale MF³
Celani C³
Romeo M⁴
Patroniti S⁴
Gentile C⁶
Vitale A²
Caggiano V²
Gaggiano C²
Diomeda F⁸
Cattalini M⁹
Lopalco G¹⁰
Emmi G^{11, 12}
Parronchi P¹¹
Gentileschi S²
Cardinale F¹
Aragona E¹³
Shahram F¹⁴
Marino A¹⁵
Barone P¹⁶
Moscheo C¹⁷
Ozkiziltas B¹⁸
Carubbi F¹⁹
Alahmed O²⁰
Iezzi L²¹
Ogunjimi B^{22, 23}
Mauro A²⁴
Tarsia M²⁵
Mahmoud AAMA²⁶
Giardini HAM²⁷
Sfikakis PP²⁸
Laskari K²⁸
Wiesikszewczyk E²⁹
Hernandezrodriguez J³⁰
Frediani B²
Gomezcaverzaschi V³⁰
Tufan A¹⁸
Almaghlouth IA^{31, 32}
Balistreri A³³
Ragab G^{26, 34}
Fabiani C³⁵
Cantarini L²
Rigante D^{21, 36}

Source: Frontiers in Medicine Published:2023

Abstract

Objective: To evaluate the potential role of Streptococcus salivarius K12 (SSK12) in controlling febrile flares in patients with Periodic Fever, Aphthous stomatitis, Pharyngitis, and cervical Adenitis (PFAPA) syndrome. Further aims were to assess the impact of SSK12 on (i) flare duration, (ii) variation in the degree of the highest body temperature during flares, (iii) steroid-sparing effect, and (iv) change of PFAPA accompanying symptoms before and after SSK12 introduction. Patients and methods: The medical charts from 85 pediatric patients with PFAPA syndrome (49 males and 36 females) enrolled in the AIDA registry and treated with SSK12 for a median period of 6.00 ± 7.00 months in the period between September 2017 and May 2022 were examined. Children recruited had a median time of disease duration of 19.00 ± 28.00 months. Results: The number of febrile flares significantly decreased comparing the 12 months before [median (IQR), 13.00 (6.00)] and after SSK12 initiation [median (IQR), 5.50 (8.00), p < 0.001]. The duration of fever was significantly reduced from 4.00 (2.00) days to 2.00 (2.00) days [p < 0.001]. Similarly, the highest temperature in°C was found significantly lower in the last follow-up assessment [median (IQR), 39.00 (1.00)] compared to the period prior to SSK12 start [median (IQR), 40.00 (1.00), p < 0.001]. Steroid load (mg/year) of betamethasone (or any equivalent steroid) significantly decreased between 12 months before treatment with SSK12 [median (IQR), 5.00 (8.00) mg/year] and the last follow-up visit [median (IQR), 2.00 (4.00) mg/year, p < 0.001]. The number of patients experiencing symptoms including pharyngitis/tonsillitis (p < 0.001), oral aphthae (p < 0.001) and cervical lymphadenopathy (p < 0.001) significantly decreased following SSK12. Conclusion: SSK12 prophylaxis given for at least 6.00 months was found to reduce febrile flares of PFAPA syndrome: in particular, it halved the total number per year of fever flares, shortened the duration of the single febrile episode, lowered body temperature by 1°C in the febrile flare, provided a steroid-sparing effect, and significantly reduced the accompanying symptoms related to the syndrome. Copyright © 2023 La Torre, Sota, Insalaco, Conti, Del Giudice, Lubrano, Breda, Maggio, Civino, Mastrorilli, Loconte, Natale, Celani, Romeo, Patroniti, Gentile, Vitale, Caggiano, Gaggiano, Diomeda, Cattalini, Lopalco, Emmi, Parronchi, Gentileschi, Cardinale, Aragona, Shahram, Marino, Barone, Moscheo, Ozkiziltas, Carubbi, Alahmed, Iezzi, Ogunjimi, Mauro, Tarsia, Mahmoud, Giardini, Sfikakis, Laskari, Wiesik-Szewczyk, Hernandez-Rodriguez, Frediani, Gomez-Caverzaschi, Tufan, Almaghlouth, Balistreri, Ragab, Fabiani, Cantarini and Rigante.

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Style	Citing Format
MLA	La Torre F, et al.. "Preliminary Data Revealing Efficacy of Streptococcus Salivarius K12 (Ssk12) in Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (Pfapa) Syndrome: A Multicenter Study From the Aida Network Pfapa Syndrome Registry." Frontiers in Medicine, vol. 10, no. , 2023, pp. -.
APA	La Torre F, Sota J, Insalaco A, Conti G, Del Giudice E, Lubrano R, Breda L, Maggio MC, Civino A, Mastrorilli V, Loconte R, Natale MF, Celani C, Romeo M, Patroniti S, Gentile C, Vitale A, Caggiano V, Gaggiano C, ... Rigante D (2023). Preliminary Data Revealing Efficacy of Streptococcus Salivarius K12 (Ssk12) in Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (Pfapa) Syndrome: A Multicenter Study From the Aida Network Pfapa Syndrome Registry. Frontiers in Medicine, 10(), -.
Chicago	La Torre F, Sota J, Insalaco A, Conti G, Del Giudice E, Lubrano R, Breda L, et al.. "Preliminary Data Revealing Efficacy of Streptococcus Salivarius K12 (Ssk12) in Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (Pfapa) Syndrome: A Multicenter Study From the Aida Network Pfapa Syndrome Registry." Frontiers in Medicine 10, no. (2023): -.
Harvard	La Torre F et al. (2023) 'Preliminary Data Revealing Efficacy of Streptococcus Salivarius K12 (Ssk12) in Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (Pfapa) Syndrome: A Multicenter Study From the Aida Network Pfapa Syndrome Registry', Frontiers in Medicine, 10(), pp. -.
Vancouver	La Torre F, Sota J, Insalaco A, Conti G, Del Giudice E, Lubrano R, et al.. Preliminary Data Revealing Efficacy of Streptococcus Salivarius K12 (Ssk12) in Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (Pfapa) Syndrome: A Multicenter Study From the Aida Network Pfapa Syndrome Registry. Frontiers in Medicine. 2023;10():-.
BibTex	@article{ author = {La Torre F and Sota J and Insalaco A and Conti G and Del Giudice E and Lubrano R and Breda L and Maggio MC and Civino A and Mastrorilli V and Loconte R and Natale MF and Celani C and Romeo M and Patroniti S and Gentile C and Vitale A and Caggiano V and Gaggiano C and Diomeda F and Cattalini M and Lopalco G and Emmi G and Parronchi P and Gentileschi S and Cardinale F and Aragona E and Shahram F and Marino A and Barone P and Moscheo C and Ozkiziltas B and Carubbi F and Alahmed O and Iezzi L and Ogunjimi B and Mauro A and Tarsia M and Mahmoud AAMA and Giardini HAM and Sfikakis PP and Laskari K and Wiesikszewczyk E and Hernandezrodriguez J and Frediani B and Gomezcaverzaschi V and Tufan A and Almaghlouth IA and Balistreri A and Ragab G and Fabiani C and Cantarini L and Rigante D}, title = {Preliminary Data Revealing Efficacy of Streptococcus Salivarius K12 (Ssk12) in Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (Pfapa) Syndrome: A Multicenter Study From the Aida Network Pfapa Syndrome Registry}, journal = {Frontiers in Medicine}, volume = {10}, number = {}, pages = {-}, year = {2023} }
RIS	TY - JOUR AU - La Torre F AU - Sota J AU - Insalaco A AU - Conti G AU - Del Giudice E AU - Lubrano R AU - Breda L AU - Maggio MC AU - Civino A AU - Mastrorilli V AU - Loconte R AU - Natale MF AU - Celani C AU - Romeo M AU - Patroniti S AU - Gentile C AU - Vitale A AU - Caggiano V AU - Gaggiano C AU - Diomeda F AU - Cattalini M AU - Lopalco G AU - Emmi G AU - Parronchi P AU - Gentileschi S AU - Cardinale F AU - Aragona E AU - Shahram F AU - Marino A AU - Barone P AU - Moscheo C AU - Ozkiziltas B AU - Carubbi F AU - Alahmed O AU - Iezzi L AU - Ogunjimi B AU - Mauro A AU - Tarsia M AU - Mahmoud AAMA AU - Giardini HAM AU - Sfikakis PP AU - Laskari K AU - Wiesikszewczyk E AU - Hernandezrodriguez J AU - Frediani B AU - Gomezcaverzaschi V AU - Tufan A AU - Almaghlouth IA AU - Balistreri A AU - Ragab G AU - Fabiani C AU - Cantarini L AU - Rigante D TI - Preliminary Data Revealing Efficacy of Streptococcus Salivarius K12 (Ssk12) in Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (Pfapa) Syndrome: A Multicenter Study From the Aida Network Pfapa Syndrome Registry JO - Frontiers in Medicine VL - 10 IS - SP - EP - PY - 2023 ER -

Style

Citing Format

MLA

La Torre F, et al.. "Preliminary Data Revealing Efficacy of Streptococcus Salivarius K12 (Ssk12) in Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (Pfapa) Syndrome: A Multicenter Study From the Aida Network Pfapa Syndrome Registry." Frontiers in Medicine, vol. 10, no. , 2023, pp. -.

APA

La Torre F, Sota J, Insalaco A, Conti G, Del Giudice E, Lubrano R, Breda L, Maggio MC, Civino A, Mastrorilli V, Loconte R, Natale MF, Celani C, Romeo M, Patroniti S, Gentile C, Vitale A, Caggiano V, Gaggiano C, ... Rigante D (2023). Preliminary Data Revealing Efficacy of Streptococcus Salivarius K12 (Ssk12) in Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (Pfapa) Syndrome: A Multicenter Study From the Aida Network Pfapa Syndrome Registry. Frontiers in Medicine, 10(), -.

Chicago

La Torre F, Sota J, Insalaco A, Conti G, Del Giudice E, Lubrano R, Breda L, et al.. "Preliminary Data Revealing Efficacy of Streptococcus Salivarius K12 (Ssk12) in Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (Pfapa) Syndrome: A Multicenter Study From the Aida Network Pfapa Syndrome Registry." Frontiers in Medicine 10, no. (2023): -.

Harvard

La Torre F et al. (2023) 'Preliminary Data Revealing Efficacy of Streptococcus Salivarius K12 (Ssk12) in Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (Pfapa) Syndrome: A Multicenter Study From the Aida Network Pfapa Syndrome Registry', Frontiers in Medicine, 10(), pp. -.

Vancouver

La Torre F, Sota J, Insalaco A, Conti G, Del Giudice E, Lubrano R, et al.. Preliminary Data Revealing Efficacy of Streptococcus Salivarius K12 (Ssk12) in Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (Pfapa) Syndrome: A Multicenter Study From the Aida Network Pfapa Syndrome Registry. Frontiers in Medicine. 2023;10():-.

BibTex

@article{ author = {La Torre F and Sota J and Insalaco A and Conti G and Del Giudice E and Lubrano R and Breda L and Maggio MC and Civino A and Mastrorilli V and Loconte R and Natale MF and Celani C and Romeo M and Patroniti S and Gentile C and Vitale A and Caggiano V and Gaggiano C and Diomeda F and Cattalini M and Lopalco G and Emmi G and Parronchi P and Gentileschi S and Cardinale F and Aragona E and Shahram F and Marino A and Barone P and Moscheo C and Ozkiziltas B and Carubbi F and Alahmed O and Iezzi L and Ogunjimi B and Mauro A and Tarsia M and Mahmoud AAMA and Giardini HAM and Sfikakis PP and Laskari K and Wiesikszewczyk E and Hernandezrodriguez J and Frediani B and Gomezcaverzaschi V and Tufan A and Almaghlouth IA and Balistreri A and Ragab G and Fabiani C and Cantarini L and Rigante D}, title = {Preliminary Data Revealing Efficacy of Streptococcus Salivarius K12 (Ssk12) in Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (Pfapa) Syndrome: A Multicenter Study From the Aida Network Pfapa Syndrome Registry}, journal = {Frontiers in Medicine}, volume = {10}, number = {}, pages = {-}, year = {2023} }

RIS

TY - JOUR
AU - La Torre F
AU - Sota J
AU - Insalaco A
AU - Conti G
AU - Del Giudice E
AU - Lubrano R
AU - Breda L
AU - Maggio MC
AU - Civino A
AU - Mastrorilli V
AU - Loconte R
AU - Natale MF
AU - Celani C
AU - Romeo M
AU - Patroniti S
AU - Gentile C
AU - Vitale A
AU - Caggiano V
AU - Gaggiano C
AU - Diomeda F
AU - Cattalini M
AU - Lopalco G
AU - Emmi G
AU - Parronchi P
AU - Gentileschi S
AU - Cardinale F
AU - Aragona E
AU - Shahram F
AU - Marino A
AU - Barone P
AU - Moscheo C
AU - Ozkiziltas B
AU - Carubbi F
AU - Alahmed O
AU - Iezzi L
AU - Ogunjimi B
AU - Mauro A
AU - Tarsia M
AU - Mahmoud AAMA
AU - Giardini HAM
AU - Sfikakis PP
AU - Laskari K
AU - Wiesikszewczyk E
AU - Hernandezrodriguez J
AU - Frediani B
AU - Gomezcaverzaschi V
AU - Tufan A
AU - Almaghlouth IA
AU - Balistreri A
AU - Ragab G
AU - Fabiani C
AU - Cantarini L
AU - Rigante D
TI - Preliminary Data Revealing Efficacy of Streptococcus Salivarius K12 (Ssk12) in Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (Pfapa) Syndrome: A Multicenter Study From the Aida Network Pfapa Syndrome Registry
JO - Frontiers in Medicine
VL - 10
IS -
SP -
EP -
PY - 2023
ER -

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