Neuregulin1 Gene Variants As a Biomarker for Cognitive Impairments in Patients With Schizophrenia Publisher



Ananloo ES^{1, 2} ; Yoosefee S^{3, 4} ; Karimipour M⁵
Source: European Journal of Psychiatry Published:2020

Abstract

Background and objectives: This study aimed to determine whether the selected neuregulin1 (NRG1) gene variants (rs2439272 and rs6988339) are associated with schizophrenia, and Cognitive Impairments Associated with Schizophrenia (CIAS). Methods: Participants with schizophrenia (N = 276) and healthy controls (N = 193) were enrolled. Cognitive assessment using the Wisconsin card sorting test (WCST) and Wechsler adult intelligence scale and genotyping for selected variants of NRG1 were performed. Results: For both the rs2439272 and rs6988339, compared to healthy controls, we found significant higher frequencies of the G allele and the GG genotype in all and male participants with schizophrenia, and with all Wechsler adult intelligence score (WAIS) and Wisconsin card sorting test (WCST) scores (except for non-perseverative score) in all, male and female participants. Conclusions: There was an association between rs2439272, rs6988339 of NRG1 variants and schizophrenia and CIAS (intelligence and executive functions). © 2019 Asociacion Universitaria de Zaragoza para el Progreso de la Psiquiatria y la Salud Mental