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Hippocampal Dhcr24 Down Regulation in a Rat Model of Streptozotocin-Induced Cognitive Decline Publisher Pubmed



Hosseinzadeh S1 ; Zahmatkesh M1 ; Heidari M2 ; Hassanzadeh GR1, 3 ; Karimian M1, 4 ; Sarrafnejad A5 ; Zarrindast MR1
Authors

Source: Neuroscience Letters Published:2015


Abstract

The DHCR24 (24-dehydrocholesterol reductase) gene codes a multifunctional protein which consists of enzymatic, antioxidant, and anti-apoptotic activities. It exists in almost all neurons and protects the neural cells against amyloid β toxicity. Several studies have shown the down regulation of DHCR24 in Alzheimer's disease. We examined the time profile of DHCR24-mRNA alteration in an animal model of streptozotocin (STZ)-induced cognitive impairment. The DHCR24 mRNA levels of hippocampus and cognitive impairment were evaluated at 7, 14, and 21 days after intracerebroventricular (ICV)-STZ/Saline administration. DHCR24 expression was down regulated at 14 and 21 days after ICV-STZ administration. The decrease in expression of DHCR24 preceded the onset of the cognitive impairment. These results suggest the potential relation between DHCR24 expression and cognitive impairment. © 2014 Elsevier Ireland Ltd.
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