Endurance Exercise Exerts Hepatoprotection Against Electromagnetic Radiation Via Targeting Oxidative Stress in Male Rats Publisher



Amiri H ; Rakhshan K ; Shabkhiz F ; Fard RZ ; Aboutaleb N
Source: International Journal of Radiation Research Published:2025

Abstract

Background: The effects of electromagnetic radiation (EMR) on the body are an emerging field of research. The evidence supports the production of oxidative stress (OS) through EMR and the positive role of exercise in reducing liver damage. The evidence supports the production of OS through EMR and the positive role of exercise in reducing liver damage. Materials and Methods: 32 Wistar male rats were randomly divided into four groups: control, EMR, endurance training (ET), and EMR+ET. The ET and EMR+ET groups ran on the treadmill with the maximum speed and duration of 30 m/ min and 35 min, respectively (5 sessions/weeks, during four weeks). The ET and EMR+ ET groups were exposed to a 2.45GHZ Wi-Fi router for four weeks (4 h/day, 7days/weeks). Forty-eight hours after the last training session, the blood and liver tissue of the animals were sampled for histological, biochemical evaluations and measurement of oxidative stress markers. Results: Histopathological findings confirmed the protective role of ET in rats exposed to EMR. The results showed that in the EMR group, the concentration of malondialdehyde (MDA) and the serum levels of liver enzymes (AST, ALT, and ALP) increased significantly, and the activity of antioxidant enzymes decreased significantly (P<0.05). In the ET and EMR+ET groups, compared to the EMR group, the concentration of MDA and the serum levels of liver enzymes significantly decreased, and the activity of antioxidant enzymes increased significantly (P<0.05). Conclusion: Our findings show that ET can improve the state of OS and liver damage caused by EMR. © 2025, Novin Medical Radiation Institute. All rights reserved.