Endoscopic Ultrasound-Guided Radiofrequency Ablation Versus Surgical Resection for Treatment of Pancreatic Insulinoma

Endoscopic Ultrasound-Guided Radiofrequency Ablation Versus Surgical Resection for Treatment of Pancreatic Insulinoma Publisher Pubmed

Crino SF¹ ; Napoleon B² ; Facciorusso A³ ; Lakhtakia S⁴ ; Borbath I⁵ ; Caillol F⁶ ; Docong Pham K⁷ ; Rizzatti G⁸ ; Forti E⁹ ; Palazzo L¹⁰ ; Belle A¹¹ ; Vilmann P¹² ; Van Laethem JL¹³ ; Mohamadnejad M¹⁴ Show All Authors

Crino SF¹
Napoleon B²
Facciorusso A³
Lakhtakia S⁴
Borbath I⁵
Caillol F⁶
Docong Pham K⁷
Rizzatti G⁸
Forti E⁹
Palazzo L¹⁰
Belle A¹¹
Vilmann P¹²
Van Laethem JL¹³
Mohamadnejad M¹⁴
Godat S¹⁵
Hindryckx P¹⁶
Benson A¹⁷
Tacelli M¹⁸
De Nucci G¹⁹
Binda C²⁰
Kovacevic B¹²
Jacob H¹⁷
Partelli S²¹
Falconi M²¹
Salvia R²²
Landoni L²²
Alfieri S²³
Arcidiacono PG¹⁸
Arvanitakis M²⁴
Battistella A²¹
Bernadroni L¹
Brink L¹²
Cintolo M⁹
Conti Bellocchi MC¹
Davi MV²⁵
Deguelte S²⁶
Deprez P⁵
Deviere J²⁴
Ewald J²⁷
Fabbri C²⁰
Ferrari G²⁸
Furnica RM²⁹
Gabbrielli A¹
Garcesduran R²⁵
Giovannini M⁶
Gonda T³⁰
Gornals JB³¹
Marx M¹⁵
Mazzola M²⁸
Mutignani M⁹
Ofosu A³²
Pereira SP³³
Perrier M²⁶
Przybylkowski A³⁴
Repici A³⁵
Sundaram S³⁶
Tripodi G⁷
Larghi A⁷

Source: Clinical Gastroenterology and Hepatology Published:2023

Abstract

Background & Aims: Endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) is emerging as a safe and effective treatment for pancreatic neuroendocrine tumors. We aimed to compare EUS-RFA and surgical resection for the treatment of pancreatic insulinoma (PI). Methods: Patients with sporadic PI who underwent EUS-RFA at 23 centers or surgical resection at 8 high-volume pancreatic surgery institutions between 2014 and 2022 were retrospectively identified and outcomes compared using a propensity-matching analysis. Primary outcome was safety. Secondary outcomes were clinical efficacy, hospital stay, and recurrence rate after EUS-RFA. Results: Using propensity score matching, 89 patients were allocated in each group (1:1), and were evenly distributed in terms of age, sex, Charlson comorbidity index, American Society of Anesthesiologists score, body mass index, distance between lesion and main pancreatic duct, lesion site, size, and grade. Adverse event (AE) rate was 18.0% and 61.8% after EUS-RFA and surgery, respectively (P < .001). No severe AEs were observed in the EUS-RFA group compared with 15.7% after surgery (P < .0001). Clinical efficacy was 100% after surgery and 95.5% after EUS-RFA (P = .160). However, the mean duration of follow-up time was shorter in the EUS-RFA group (median, 23 months; interquartile range, 14-31 months vs 37 months; interquartile range, 17.5-67 months in the surgical group; P < .0001). Hospital stay was significantly longer in the surgical group (11.1 ± 9.7 vs 3.0 ± 2.5 days in the EUS-RFA group; P < .0001). Fifteen lesions (16.9%) recurred after EUS-RFA and underwent a successful repeat EUS-RFA (11 patients) or surgical resection (4 patients). Conclusion: EUS-RFA is safer than surgery and highly effective for the treatment of PI. If confirmed in a randomized study, EUS-RFA treatment can become first-line therapy for sporadic PI. © 2023 AGA Institute

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Style	Citing Format
MLA	Crino SF, et al.. "Endoscopic Ultrasound-Guided Radiofrequency Ablation Versus Surgical Resection for Treatment of Pancreatic Insulinoma." Clinical Gastroenterology and Hepatology, vol. 21, no. 11, 2023, pp. 2834-2843.e2.
APA	Crino SF, Napoleon B, Facciorusso A, Lakhtakia S, Borbath I, Caillol F, Docong Pham K, Rizzatti G, Forti E, Palazzo L, Belle A, Vilmann P, Van Laethem JL, Mohamadnejad M, Godat S, Hindryckx P, Benson A, Tacelli M, De Nucci G, ... Larghi A (2023). Endoscopic Ultrasound-Guided Radiofrequency Ablation Versus Surgical Resection for Treatment of Pancreatic Insulinoma. Clinical Gastroenterology and Hepatology, 21(11), 2834-2843.e2.
Chicago	Crino SF, Napoleon B, Facciorusso A, Lakhtakia S, Borbath I, Caillol F, Docong Pham K, et al.. "Endoscopic Ultrasound-Guided Radiofrequency Ablation Versus Surgical Resection for Treatment of Pancreatic Insulinoma." Clinical Gastroenterology and Hepatology 21, no. 11 (2023): 2834-2843.e2.
Harvard	Crino SF et al. (2023) 'Endoscopic Ultrasound-Guided Radiofrequency Ablation Versus Surgical Resection for Treatment of Pancreatic Insulinoma', Clinical Gastroenterology and Hepatology, 21(11), pp. 2834-2843.e2.
Vancouver	Crino SF, Napoleon B, Facciorusso A, Lakhtakia S, Borbath I, Caillol F, et al.. Endoscopic Ultrasound-Guided Radiofrequency Ablation Versus Surgical Resection for Treatment of Pancreatic Insulinoma. Clinical Gastroenterology and Hepatology. 2023;21(11):2834-2843.e2.
BibTex	@article{ author = {Crino SF and Napoleon B and Facciorusso A and Lakhtakia S and Borbath I and Caillol F and Docong Pham K and Rizzatti G and Forti E and Palazzo L and Belle A and Vilmann P and Van Laethem JL and Mohamadnejad M and Godat S and Hindryckx P and Benson A and Tacelli M and De Nucci G and Binda C and Kovacevic B and Jacob H and Partelli S and Falconi M and Salvia R and Landoni L and Alfieri S and Arcidiacono PG and Arvanitakis M and Battistella A and Bernadroni L and Brink L and Cintolo M and Conti Bellocchi MC and Davi MV and Deguelte S and Deprez P and Deviere J and Ewald J and Fabbri C and Ferrari G and Furnica RM and Gabbrielli A and Garcesduran R and Giovannini M and Gonda T and Gornals JB and Marx M and Mazzola M and Mutignani M and Ofosu A and Pereira SP and Perrier M and Przybylkowski A and Repici A and Sundaram S and Tripodi G and Larghi A}, title = {Endoscopic Ultrasound-Guided Radiofrequency Ablation Versus Surgical Resection for Treatment of Pancreatic Insulinoma}, journal = {Clinical Gastroenterology and Hepatology}, volume = {21}, number = {11}, pages = {2834-2843.e2}, year = {2023} }
RIS	TY - JOUR AU - Crino SF AU - Napoleon B AU - Facciorusso A AU - Lakhtakia S AU - Borbath I AU - Caillol F AU - Docong Pham K AU - Rizzatti G AU - Forti E AU - Palazzo L AU - Belle A AU - Vilmann P AU - Van Laethem JL AU - Mohamadnejad M AU - Godat S AU - Hindryckx P AU - Benson A AU - Tacelli M AU - De Nucci G AU - Binda C AU - Kovacevic B AU - Jacob H AU - Partelli S AU - Falconi M AU - Salvia R AU - Landoni L AU - Alfieri S AU - Arcidiacono PG AU - Arvanitakis M AU - Battistella A AU - Bernadroni L AU - Brink L AU - Cintolo M AU - Conti Bellocchi MC AU - Davi MV AU - Deguelte S AU - Deprez P AU - Deviere J AU - Ewald J AU - Fabbri C AU - Ferrari G AU - Furnica RM AU - Gabbrielli A AU - Garcesduran R AU - Giovannini M AU - Gonda T AU - Gornals JB AU - Marx M AU - Mazzola M AU - Mutignani M AU - Ofosu A AU - Pereira SP AU - Perrier M AU - Przybylkowski A AU - Repici A AU - Sundaram S AU - Tripodi G AU - Larghi A TI - Endoscopic Ultrasound-Guided Radiofrequency Ablation Versus Surgical Resection for Treatment of Pancreatic Insulinoma JO - Clinical Gastroenterology and Hepatology VL - 21 IS - 11 SP - 2834 EP - 2843.e2 PY - 2023 ER -

Style

Citing Format

MLA

Crino SF, et al.. "Endoscopic Ultrasound-Guided Radiofrequency Ablation Versus Surgical Resection for Treatment of Pancreatic Insulinoma." Clinical Gastroenterology and Hepatology, vol. 21, no. 11, 2023, pp. 2834-2843.e2.

APA

Crino SF, Napoleon B, Facciorusso A, Lakhtakia S, Borbath I, Caillol F, Docong Pham K, Rizzatti G, Forti E, Palazzo L, Belle A, Vilmann P, Van Laethem JL, Mohamadnejad M, Godat S, Hindryckx P, Benson A, Tacelli M, De Nucci G, ... Larghi A (2023). Endoscopic Ultrasound-Guided Radiofrequency Ablation Versus Surgical Resection for Treatment of Pancreatic Insulinoma. Clinical Gastroenterology and Hepatology, 21(11), 2834-2843.e2.

Chicago

Crino SF, Napoleon B, Facciorusso A, Lakhtakia S, Borbath I, Caillol F, Docong Pham K, et al.. "Endoscopic Ultrasound-Guided Radiofrequency Ablation Versus Surgical Resection for Treatment of Pancreatic Insulinoma." Clinical Gastroenterology and Hepatology 21, no. 11 (2023): 2834-2843.e2.

Harvard

Crino SF et al. (2023) 'Endoscopic Ultrasound-Guided Radiofrequency Ablation Versus Surgical Resection for Treatment of Pancreatic Insulinoma', Clinical Gastroenterology and Hepatology, 21(11), pp. 2834-2843.e2.

Vancouver

Crino SF, Napoleon B, Facciorusso A, Lakhtakia S, Borbath I, Caillol F, et al.. Endoscopic Ultrasound-Guided Radiofrequency Ablation Versus Surgical Resection for Treatment of Pancreatic Insulinoma. Clinical Gastroenterology and Hepatology. 2023;21(11):2834-2843.e2.

BibTex

@article{ author = {Crino SF and Napoleon B and Facciorusso A and Lakhtakia S and Borbath I and Caillol F and Docong Pham K and Rizzatti G and Forti E and Palazzo L and Belle A and Vilmann P and Van Laethem JL and Mohamadnejad M and Godat S and Hindryckx P and Benson A and Tacelli M and De Nucci G and Binda C and Kovacevic B and Jacob H and Partelli S and Falconi M and Salvia R and Landoni L and Alfieri S and Arcidiacono PG and Arvanitakis M and Battistella A and Bernadroni L and Brink L and Cintolo M and Conti Bellocchi MC and Davi MV and Deguelte S and Deprez P and Deviere J and Ewald J and Fabbri C and Ferrari G and Furnica RM and Gabbrielli A and Garcesduran R and Giovannini M and Gonda T and Gornals JB and Marx M and Mazzola M and Mutignani M and Ofosu A and Pereira SP and Perrier M and Przybylkowski A and Repici A and Sundaram S and Tripodi G and Larghi A}, title = {Endoscopic Ultrasound-Guided Radiofrequency Ablation Versus Surgical Resection for Treatment of Pancreatic Insulinoma}, journal = {Clinical Gastroenterology and Hepatology}, volume = {21}, number = {11}, pages = {2834-2843.e2}, year = {2023} }

RIS

TY - JOUR
AU - Crino SF
AU - Napoleon B
AU - Facciorusso A
AU - Lakhtakia S
AU - Borbath I
AU - Caillol F
AU - Docong Pham K
AU - Rizzatti G
AU - Forti E
AU - Palazzo L
AU - Belle A
AU - Vilmann P
AU - Van Laethem JL
AU - Mohamadnejad M
AU - Godat S
AU - Hindryckx P
AU - Benson A
AU - Tacelli M
AU - De Nucci G
AU - Binda C
AU - Kovacevic B
AU - Jacob H
AU - Partelli S
AU - Falconi M
AU - Salvia R
AU - Landoni L
AU - Alfieri S
AU - Arcidiacono PG
AU - Arvanitakis M
AU - Battistella A
AU - Bernadroni L
AU - Brink L
AU - Cintolo M
AU - Conti Bellocchi MC
AU - Davi MV
AU - Deguelte S
AU - Deprez P
AU - Deviere J
AU - Ewald J
AU - Fabbri C
AU - Ferrari G
AU - Furnica RM
AU - Gabbrielli A
AU - Garcesduran R
AU - Giovannini M
AU - Gonda T
AU - Gornals JB
AU - Marx M
AU - Mazzola M
AU - Mutignani M
AU - Ofosu A
AU - Pereira SP
AU - Perrier M
AU - Przybylkowski A
AU - Repici A
AU - Sundaram S
AU - Tripodi G
AU - Larghi A
TI - Endoscopic Ultrasound-Guided Radiofrequency Ablation Versus Surgical Resection for Treatment of Pancreatic Insulinoma
JO - Clinical Gastroenterology and Hepatology
VL - 21
IS - 11
SP - 2834
EP - 2843.e2
PY - 2023
ER -

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