Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Pregabalin in Patients With Post-Traumatic Peripheral Neuropathic Pain: A Meta-Analysis of Randomized Controlled Trials Publisher Pubmed



Maleki MS1 ; Zamani Z2 ; Amiri R3 ; Kakhki S4 ; Jafari M5 ; Amani B6 ; Amani B6 ; Amanat N2
Authors

Source: Pain Practice Published:2023


Abstract

Objective: The aim of the study was to investigate the safety and efficacy of pregabalin versus placebo in post-traumatic peripheral neuropathic pain (PTNP). Methods: PubMed, Cochrane Library, Web of Science, and Google Scholar were searched for relevant evidence up to January 2022. The Cochran tool was used to assess the quality of randomized clinical trials (RCTs). Data analysis was performed using Comprehensive Meta-Analysis software. Results: Three RCTs involving 821 patients were included in the meta-analysis. A significant difference was observed between pregabalin and placebo in terms of the pain score (the standardized mean difference [SMD] = −0.14, 95% CI: 0.28 to −0.006, p = 0.04) and sleep interference (MD = −0.25, 95% CI: −0.39 to −0.11, p = 0.00). There was also a significant difference between pregabalin and placebo regarding somnolence (risk ratio [RR] = 2.78; 95% CI: 1.64–4.71, p = 0.00), dizziness (RR = 4.13; 95% CI: 2.71–6.28, p = 0.00), and disturbance in attention (RR: 2.97; 95% CI: 1.02–8.65, p = 0.04). However, no significant difference was observed between pregabalin and placebo in terms of headache (RR = 1.20; 95% CI: 0.70–2.06, p = 0.50), fatigue (RR = 1.42; 95% CI: 0.82–2.47, p = 0.20), nausea (RR = 1.52; 95% CI: 0.88–2.62, p = 0.13), constipation (RR = 1.84; 95% CI: 0.78–4.29, p = 0.15), and discontinuation (RR = 1.52; 95% CI: 0.45–5.06, p = 0.49). Conclusion: Compared with placebo, pregabalin showed better efficacy in reducing PTNP and improving sleep interference. However, it was associated with higher adverse events. Further RCTs are needed to confirm these findings. © 2023 World Institute of Pain.
Other Related Docs
12. Combined Treatment With Minocycline and Methylprednisolone in Acute Traumatic Spinal Cord Injury: A Pilot Study, Interdisciplinary Neurosurgery: Advanced Techniques and Case Management (2024)