Tehran University of Medical Sciences

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Rajaei S1
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Source: Encyclopedia of Infection and Immunity Published:2022


Abstract

Cellular immune responses, mediated by CD4+ and CD8+ T cells, play a major role in defense against intracellular and extracellular bacteria as well as immunity against tumors. Different subsets of effector CD4+ T lymphocytes (e.g., Th1, Th2, and Th17) provide help to other leukocytes to efficiently eradicate extracellular bacteria while effector CD8+ T lymphocytes (e.g., CTLs) directly kill the cells infected with viruses or intracellular bacteria. In this chapter, the stages of T cell activation, and also the effector T cell responses to diverse pathogens will be discussed. © 2022 Elsevier Inc. All rights reserved.
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