Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
The Potential Use of Bacteriophages As Antibacterial Agents in Dental Infection Publisher Pubmed

Summary: Fight dental bugs? Study finds phages target S. mutans, P. gingivalis—disrupt biofilms. Suggests antibiotic alternative. #DentalInfections #Bacteriophage

Hosseini Hooshiar M1 ; Salari S2 ; Nasiri K3 ; Salim US4 ; Saeed LM5 ; Yasamineh S6 ; Safaralizadeh R7
Authors

Source: Virology Journal Published:2024


Abstract

Dental infections, such as apical Periodontitis, periodontitis, and peri-implantitis (PI), are closely associated with specific bacterial species, including Streptococcus mutans (S. mutans), Porphyromonas gingivalis (P. gingivalis), and Fusobacterium nucleatum (F. nucleatum), among others. Antibiotics are extensively utilized for prophylactic and therapeutic purposes in the treatment of dental infections and other dental-related issues. Unfortunately, the rapid emergence of antimicrobial resistance has accompanied the increased use of antibiotics in recent years. Specific bacterial pathogens have reached a critical stage of antibiotic resistance, characterized by the proliferation of pan-resistant strains and the scarcity of viable therapeutic alternatives. Therapeutic use of particular bacteriophage (phage) particles that target bacterial pathogens is one potential alternative to antibiotics that are now being seriously considered for treating bacterial illnesses. A kind of virus known as a phage is capable of infecting and eliminating bacteria. Because they can’t infect cells in plants and animals, phages might be a harmless substitute for antibiotics. To control oral disorders including periodontitis and dental caries, several research have been conducted in this area to study and identify phages from human saliva and dental plaque. The capacity of these agents to disturb biofilms expands their effectiveness against dental plaque biofilms and oral pathogens in cases of periodontitis, PI, and apical periodontitis. This review summarizes the current antibacterial properties of phages used to treat a variety of dental infections, such as periodontitis, peri-implantitis, infected dentin, and apical periodontitis. Graphical Abstract: (Figure presented.) © The Author(s) 2024.
Related Docs
View other Related Docs
1. Recent Advances in Metal Nanoparticles to Treat Periodontitis, Journal of Nanobiotechnology (2023)
2. Oral Bacteriophages: Metagenomic Clues to Interpret Microbiomes, PeerJ (2024)
3. Comparison of the Effect of Extracted Bacteriocin and Lytic Bacteriophage on the Expression of Biofilm Associated Genes in Streptococcus Mutans, Advances in Materials Science and Engineering (2022)
Experts (# of related papers)
View all Related Experts
Maryam Pourhajibagher (6)
Abbas Bahador (6)
The Potential Use of Bacteriophages As Antibacterial Agents in Dental Infection
Other Related Docs
4. Effect of Isolated Specific Lytic Phage Against Growth and Biofilm Inhibition of Streptococcus Mutans and Streptococcus Sanguinis Isolated From Decayed Dental Plaque, Journal of Mazandaran University of Medical Sciences (2023)
5. A Review of the Fighting Acinetobacter Baumannii on Three Fronts: Antibiotics, Phages, and Nanoparticles, Molecular Biology Reports (2024)
6. A Mini-Review on New Disinfection Alternative: Bacteriophages and Pathogen Removal Potential From Water and Wastewater, Desalination and Water Treatment (2017)
7. Predicting the Future: Phage Therapy, Egyptian Journal of Veterinary Science(Egypt) (2022)
8. Combined Forces Against Bacteria: Phages and Antibiotics, Health Science Reports (2025)
9. Isolation, Characterization, and Genomic Analysis of Vb_Paes_Tums_P81, a Lytic Bacteriophage Against Pseudomonas Aeruginosa, Virus Genes (2023)
10. Isolation and Identification of Specific Bacteriophage Against Enteropathogenic Escherichia Coli (Epec) and in Vitro and in Vivo Characterization of Bacteriophage, FEMS Microbiology Letters (2018)
11. A Novel Broad-Spectrum Bacteriophage Cocktail Against Methicillin-Resistant Staphylococcus Aureus: Isolation, Characterization, and Therapeutic Potential in a Mastitis Mouse Model, PLoS ONE (2025)
12. Gene Expression Profiling of Fima Gene Encoding Fimbriae Among Clinical Isolates of Porphyromonas Gingivalis in Response to Photo-Activated Disinfection Therapy, Photodiagnosis and Photodynamic Therapy (2017)
13. Investigation of Arginine A-Specific Cysteine Proteinase Gene Expression Profiling in Clinical Porphyromonas Gingivalis Isolates Against Photokilling Action of the Photo-Activated Disinfection, Lasers in Medical Science (2018)
14. Exploring Photoactivated Disinfection-Induced Bystander Effects on Microbial Biofilms of Aggregatibacter Actinomycetemcomitans, Infectious Disorders - Drug Targets (2021)
15. Mechanism of Action and Application of Virocids in Health Careassociated Viral Infections, Tehran University Medical Journal (2016)
16. Monitoring of Virulence Factors and Metabolic Activity in Aggregatibacter Actinomycetemcomitans Cells Surviving Antimicrobial Photodynamic Therapy Via Nano-Chitosan Encapsulated Indocyanine Green, Frontiers in Physics (2018)
17. Early Detection of Oral Bacteria Causing Gum Infections and Dental Caries in Children, Iranian Journal of Microbiology (2024)
18. Biomaterials and Biological Parameters for Fixed-Prosthetic Implant-Supported Restorations: A Review Study, Advances in Materials Science and Engineering (2022)
19. Photo-Activated Disinfection Based on Indocyanine Green Against Cell Viability and Biofilm Formation of Porphyromonas Gingivalis, Photodiagnosis and Photodynamic Therapy (2017)
20. Investigation of the Effect of Probiotics and Specific Bacteriophages on the Biofilm Formed by Streptococcus Mutans, Microbe (Netherlands) (2025)