Real-Time Compression Feedback for Patients With In-Hospital Cardiac Arrest: A Multi-Center Randomized Controlled Clinical Trial Publisher



Goharani R¹ ; Vahedianazimi A² ; Farzanegan B³ ; Bashar FR⁴ ; Hajiesmaeili M¹ ; Shojaei S¹ ; Madani SJ⁵ ; Goharimoghaddam K⁶ ; Hatamian S⁷ ; Mosavinasab SMM⁸ ; Khoshfetrat M⁹ ; Khabiri Khatir MA¹⁰ ; Miller AC¹¹
Source: Journal of Intensive Care Published:2019

Abstract

Objective: To determine if real-time compression feedback using a non-automated hand-held device improves patient outcomes from in-hospital cardiac arrest (IHCA). Methods: We conducted a prospective, randomized, controlled, parallel study (no crossover) of patients with IHCA in the mixed medical-surgical intensive care units (ICUs) of eight academic hospitals. Patients received either standard manual chest compressions or compressions performed with real-time feedback using the Cardio First Angel™ (CFA) device. The primary outcome was sustained return of spontaneous circulation (ROSC), and secondary outcomes were survival to ICU and hospital discharge. Results: One thousand four hundred fifty-four subjects were randomized; 900 were included. Sustained ROSC was significantly improved in the CFA group (66.7% vs. 42.4%, P < 0.001), as was survival to ICU discharge (59.8% vs. 33.6%) and survival to hospital discharge (54% vs. 28.4%, P < 0.001). Outcomes were not affected by intra-group comparisons based on intubation status. ROSC, survival to ICU, and hospital discharge were noted to be improved in inter-group comparisons of non-intubated patients, but not intubated ones. Conclusion: Use of the CFA compression feedback device improved event survival and survival to ICU and hospital discharge. © 2019 The Author(s).