Diagnostic Value of the Neutrophil Lymphocyte Ratio in Discrimination Between Tuberculosis and Bacterial Community Acquired Pneumonia: A Meta-Analysis Publisher



Shojaan H¹ ; Kalami N¹ ; Ghasempour Alamdari M² ; Emami Alorizy SM³ ; Ghaedi A^{3, 4} ; Bazrgar A³ ; Khanzadeh M⁵ ; Luckewold B⁶ ; Khanzadeh S⁶
Source: Journal of Clinical Tuberculosis and Other Mycobacterial Diseases Published:2023

Abstract

Background: We conducted a systematic review and meta-analysis, based on Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines, to evaluate current literature on diagnostic value of neutrophil to lymphocyte ratio (NLR) in discrimination between tuberculosis (TB) and bacterial community acquired pneumonia (B-CAP). Methods: Literature search was conducted from July 20, 2023 using Scopus, PubMed, and Web of Science databases. STATA software (version 12.0; Stata Corporation) was used for all analyses. Results: We found that patients with TB had significantly lower levels of NLR compared to those with B-CAP (SMD = −1.09, 95 %CI = −1.78- −0.40, P = 0.002). In the quality subgroup analysis, we found that patients with TB had significantly lower level of NLR compared to those with B-CAP consistent in moderate (SMD = -0.86, 95 %CI = −2.30, 0.57, P = 0.23) and high-quality studies (SMD = -1.25, 95 %CI = -2.07, −0.42). In the subgroup analysis based on continent, we found that patients with TB had significantly lower level of NLR compared to those with B-CAP in studies performed in Asian populations (SMD = -1.37, 95 %CI = −2.13, −0.61, P < 0.001), but not on African population (SMD = -0.02, 95 %CI = −1.06, 1.02, P = 0.97). The result of this study did not change after execution of sensitivity analysis. The pooled sensitivity of NLR was 0.86 (95% CI = 0.80, 0.91), and the pooled specificity was0.88 (95% CI = 0.69, 0.95). Conclusion: Patients with TB had a significantly lower NLR levels compared to those with B-CAP, so we utilized this biomarker for distinguishing between the disorders. © 2023 The Authors