Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Retinoblastoma in Asia: Clinical Presentation and Treatment Outcomes in 2112 Patients From 33 Countries Publisher Pubmed



Kaliki S1, 14 ; Vempuluru VS1, 14 ; Mohamed A1, 14 ; Aljadiry MF2 ; Bowman R3, 4, 30, 40 ; Chawla B5 ; Hamid SA6 ; Ji X7 ; Kapelushnik N8 ; Kebudi R9, 66 ; Sthapit PR10 ; Rojanaporn D11 ; Sitorus RS12, 102 ; Yousef YA13 Show All Authors
Authors
  1. Kaliki S1, 14
  2. Vempuluru VS1, 14
  3. Mohamed A1, 14
  4. Aljadiry MF2
  5. Bowman R3, 4, 30, 40
  6. Chawla B5
  7. Hamid SA6
  8. Ji X7
  9. Kapelushnik N8
  10. Kebudi R9, 66
  11. Sthapit PR10
  12. Rojanaporn D11
  13. Sitorus RS12, 102
  14. Yousef YA13
  15. Fabian ID3, 8, 30
  16. Abdulqader RA15
  17. Aggarwal P16
  18. Ahmad A17
  19. Akib MNR18
  20. Al Mesfer SA19
  21. Al Ani MH20
  22. Albadri SAF2
  23. Angeles Alcasabas AP21
  24. Aldahmash SA22
  25. Alhaddad C23
  26. Yahya Alhussaini HH24
  27. Aljumaily U25
  28. Alkatan HM22
  29. Razzaq Mahmood Almafrachi AA26
  30. Samad Majeed Alshaheen AA15
  31. Alshammary EH27
  32. Amiruddin PO28
  33. Armytasari I29
  34. Astbury NJ30
  35. Atalay HT31
  36. Ataseven E32
  37. Atchaneeyasakul LO33
  38. Balayeva R34
  39. Bascaran C30
  40. Begimkulova AS35
  41. Bhaduri A36
  42. Bhat S37
  43. Bhattacharyya A38
  44. Blum S39
  45. Buaboonnam J33
  46. Burton MJ30
  47. Caspi S41
  48. Chaudhry S42
  49. Chen W43
  50. Chuluunbat T44
  51. Dangboon W45
  52. Das A38
  53. Das P46
  54. Das S47
  55. Du Y48
  56. Dudeja G37
  57. Eka Sutyawan IW49
  58. Fadoo Z50
  59. Faranoush M51
  60. Foster A30
  61. Frenkel S52
  62. Ghassemi F53
  63. Gomel N39
  64. Gunasekera DS54
  65. Gunduz AK55
  66. Gupta H56
  67. Gupta S57
  68. Gupta V16
  69. Hamzah N59
  70. Hasanreisoglu M31
  71. Hassan S60
  72. Haydar HA20
  73. Hongeng S61
  74. Hussein Aljanabi AN62
  75. Islamov Z63
  76. Janjua TA64
  77. Jeeva I50
  78. Jo DH65
  79. Kantar M32
  80. Keomisy J67
  81. Khan ZJ68
  82. Khaqan HA69
  83. Khetan V70
  84. Khodabande A53
  85. Kim JH71
  86. Kiratli H72
  87. Koc I72
  88. Kulvichit K73
  89. Kuntorini MW28
  90. Li C74
  91. Li K48
  92. Limbu B75
  93. Liu C76
  94. Lutfi D77
  95. Mahajan A78
  96. Maitra P70
  97. Makimbetov EK35
  98. Maktabi AMY19
  99. Manzhuova L79
  100. Masud S50
  101. Mehrvar A80
  102. Menon V81
  103. John V Mercado G21
  104. Chandra Mishra DK82
  105. Mohammad MT83
  106. Mudaliar SS56
  107. Mushtaq A17
  108. Nair AG84, 85
  109. Natarajan S84
  110. Nency YM86
  111. Neroev V87
  112. Nuruddin M88
  113. Pagarra H18
  114. Palanivelu MS82
  115. Papyan R89
  116. Peer J52
  117. Polyakov V90
  118. Qadir AO91
  119. Qayyum S17
  120. Qian J92
  121. Quah B80
  122. Rahman A94
  123. Rajkarnikar P64
  124. Ramanjulu R69
  125. Rashid R82
  126. Roy SR88
  127. Saab RH96
  128. Saakyan S87
  129. Sabhan AH2
  130. Saiju R75
  131. Sayalith P67
  132. Sedaghat A97
  133. Seth R98
  134. Shakoor SA99
  135. Sharma MK100
  136. Siddiqui SN60
  137. Singh U101
  138. Singha P45
  139. Soebagjo HD77
  140. Sultana S95
  141. Sun X103
  142. Supriyadi E29
  143. Surukrattanaskul S104
  144. Suzuki S105
  145. Tan D93
  146. Tang J7
  147. Tashvighi M80
  148. Teh KH59
  149. Tehuteru ES106
  150. Thawaba ADM24
  151. Toledano H107
  152. Le Trang D108
  153. Tripathy D109
  154. Tuncer S110
  155. Unal E111
  156. Ushakova TL90
  157. Usmanov R63
  158. Verma N57
  159. Victor AA102
  160. Vishnevskiadai V8
  161. Wang YZ112
  162. Wangtiraumnuay N104
  163. Riono WP106
  164. Wiwatwongwana A113
  165. Wiwatwongwana D113
  166. Wong ES114
  167. Wongwai P115
  168. Wu SQ116
  169. Xiang D43
  170. Xiao Y116
  171. Xu B74
  172. Xue K92
  173. Yam JC114
  174. Yang H117
  175. Yaqub MA64
  176. Yarovaya VA118
  177. Yarovoy AA118
  178. Ye H117
  179. Yuliawati P30
  180. Zhang Y112
  181. Zia N58
  182. Zondervan M30

Source: Ophthalmology Published:2024


Abstract

Purpose: To describe the clinical presentation and treatment outcomes of children who received a diagnosis of retinoblastoma in 2017 throughout Asia. Design: Multinational, prospective study including treatment-naive patients in Asia who received a diagnosis of retinoblastoma in 2017 and were followed up thereafter. Participants: A total of 2112 patients (2797 eyes) from 96 retinoblastoma treatment centers in 33 Asian countries. Interventions: Chemotherapy, radiotherapy, enucleation, and orbital exenteration. Main Outcome Measures: Enucleation and death. Results: Within the cohort, 1021 patients (48%) were from South Asia (SA), 503 patients (24%) were from East Asia (EA), 310 patients (15%) were from Southeast Asia (SEA), 218 patients (10%) were from West Asia (WA), and 60 patients (3%) were from Central Asia (CA). Mean age at presentation was 27 months (median, 23 months; range, < 1–261 months). The cohort included 1195 male patients (57%) and 917 female patients (43%). The most common presenting symptoms were leukocoria (72%) and strabismus (13%). Using the American Joint Committee on Cancer Staging Manual, Eighth Edition, classification, tumors were staged as cT1 (n = 441 [16%]), cT2 (n = 951 [34%]), cT3 (n = 1136 [41%]), cT4 (n = 267 [10%]), N1 (n = 48 [2%]), and M1 (n = 129 [6%]) at presentation. Retinoblastoma was treated with intravenous chemotherapy in 1450 eyes (52%) and 857 eyes (31%) underwent primary enucleation. Three-year Kaplan-Meier estimates for enucleation and death were 33% and 13% for CA, 18% and 4% for EA, 27% and 15% for SA, 32% and 22% for SEA, and 20% and 11% for WA (P < 0.0001 and P < 0.0001), respectively. Conclusions: At the conclusion of this study, significant heterogeneity was found in treatment outcomes of retinoblastoma among the regions of Asia. East Asia displayed better outcomes with higher rates of globe and life salvage, whereas Southeast Asia showed poorer outcomes compared with the rest of Asia. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article. © 2023 American Academy of Ophthalmology
Other Related Docs
6. Lesions Simulating Retinoblastoma at a Tertiary Care Center, Journal of Ophthalmic and Vision Research (2015)
10. Hpv Infections in Retinoblastoma: A Systematic Review, Journal of Clinical Laboratory Analysis (2021)
11. Retinoblastoma Treatment Over Time: A Review Article, Tehran University Medical Journal (2023)
13. Addition of Intravitreal Carboplatin With Melphalan for Management of Vitreous Seeding in Retinoblastoma, Graefe's Archive for Clinical and Experimental Ophthalmology (2023)