Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Hybrid-Based Design and Biological Evaluation of Quinoline-Benzoylhydrazine Based Derivatives As Α-Glucosidase Inhibitors Publisher



Ghasemi M1 ; Iraji A2, 3 ; Dehghan M4 ; Hashempur MH3 ; Mojtabavi S5 ; Faramarzi MA5 ; Mahdavi M6 ; Hamedifar H7, 8 ; Hajimiri MH7 ; Alharrasi A1
Authors

Source: Medicinal Chemistry Research Published:2025


Abstract

Diabetes mellitus, especially type 2 diabetes, is a metabolic disease that progresses with time and requires efficient management to avoid long-term problems. One promising approach to target Diabetes mellitus is to inhibit α-glucosidase to control postprandial hyperglycemia. In this work, new quinoline-benzoylhydrazine (7a–m) are designed, synthesized, and evaluated as possible α-glucosidase inhibitors. The Vilsmeier–Haack reaction was used in a multi-step process to synthesize the derivatives, and their inhibitory properties were evaluated. Kinetic analyses of the potent analog were conducted. Critical hydrogen bonding and π-π stacking interactions indicate the substantial binding affinity of the potent analog into the enzyme’s active site, as demonstrated by molecular docking and molecular mechanics with generalised born and surface area solvation (MM/GBSA) simulations. Furthermore, molecular dynamics simulations of the most potent analogs provided insights into their stability and interaction dynamics with the enzyme. These findings suggest that the designed derivatives are promising leads for developing novel α-glucosidase inhibitors to manage type 2 diabetes effectively. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2025.
Related Docs
View other Related Docs
1. Quinoline-Piperazine Derivatives As Potential Α-Glucosidase Inhibitors: Synthesis, Biological Evaluation, and in Silico Studies, Journal of Molecular Structure (2025)
2. Design and Synthesis of Novel Quinoline-Piperazines Fused to a Phenylhydrazinecarbothioamide Scaffold As Promising Α-Glucosidase Inhibitors With Anti-Diabetic Potential, Future Medicinal Chemistry (2025)
3. Substituted Piperazine Conjugated to Quinoline-Thiosemicarbazide As Potent Α-Glucosidase Inhibitors to Target Hyperglycemia, Scientific Reports (2025)
Experts (# of related papers)
View all Related Experts
Mohammad Ali Faramarzi (18)
Mohammad Mahdavi (17)
Other Related Docs
4. Synthesis and Biological Assessment of Benzimidazole-Acrylonitrile-1,2,3-Triazole Derivatives As Α-Glucosidase Inhibitors, Bioorganic Chemistry (2025)
5. Design, Synthesis, and Investigation of Novel 5-Arylpyrazole-Glucose Hybrids As Α-Glucosidase Inhibitors, Scientific Reports (2025)
6. Evaluation of Novel 2-(Quinoline-2-Ylthio)Acetamide Derivatives Linked to Diphenyl-Imidazole As Α-Glucosidase Inhibitors: Insights From in Silico, in Vitro, and in Vivo Studies on Their Anti-Diabetic Properties, European Journal of Medicinal Chemistry (2024)
7. Rational Design of New Quinoline-Benzimidazole Scaffold Bearing Piperazine Acetamide Derivatives As Antidiabetic Agents, Bioorganic Chemistry (2024)
8. Imidazo[1,2-C]Quinazolines As a Novel and Potent Scaffold of Α-Glucosidase Inhibitors: Design, Synthesis, Biological Evaluations, and in Silico Studies, Scientific Reports (2023)
9. New Phenylthiosemicarbazide-Phenoxy-1,2,3-Triazole-N-Phenylacetamides As Dual Inhibitors Against Α-Glucosidase and Ptp-1B for the Treatment of Type 2 Diabetes, Archiv der Pharmazie (2024)
10. Design, Synthesis, and Molecular Docking Studies of Diphenylquinoxaline-6-Carbohydrazide Hybrids As Potent Α-Glucosidase Inhibitors, BMC Chemistry (2022)
11. Synthesis, in Vitro Evaluation, and Molecular Docking Studies of Novel Hydrazineylideneindolinone Linked to Phenoxymethyl-1,2,3-Triazole Derivatives As Potential Α-Glucosidase Inhibitors, Bioorganic Chemistry (2021)
12. Benzoylquinazolinone Derivatives As New Potential Antidiabetic Agents: Α-Glucosidase Inhibition, Kinetic, and Docking Studies, Journal of the Chinese Chemical Society (2020)
13. Novel Pyrano[3,2-C]Quinoline-1,2,3-Triazole Hybrids As Potential Anti-Diabetic Agents: In Vitro Α-Glucosidase Inhibition, Kinetic, and Molecular Dynamics Simulation, ACS Omega (2023)
14. Synthesis, in Vitro and in Silico Enzymatic Inhibition Assays, and Toxicity Evaluations of New 4,5-Diphenylimidazole-N-Phenylacetamide Derivatives As Potent Α-Glucosidase Inhibitors, Medicinal Chemistry Research (2021)
15. Pyrano[2,3-B]Chromone Derivatives As Novel Dual Inhibitors of Α-Glucosidase and Α-Amylase: Design, Synthesis, Biological Evaluation, and in Silico Studies, Bioorganic Chemistry (2024)
16. Design and Synthesis of Novel Quinazolinone-Pyrazole Derivatives As Potential Α-Glucosidase Inhibitors: Structure-Activity Relationship, Molecular Modeling and Kinetic Study, Bioorganic Chemistry (2021)
17. Design, Synthesis, Biological Evaluation, and Molecular Modeling Studies of Pyrazole-Benzofuran Hybrids As New Α-Glucosidase Inhibitor, Scientific Reports (2021)
18. Novel Coumarin Containing Dithiocarbamate Derivatives As Potent Α-Glucosidase Inhibitors for Management of Type 2 Diabetes, Medicinal Chemistry (2021)
19. Design and Synthesis of Novel 5-Arylisoxazole-1,3,4-Thiadiazole Hybrids As Α-Glucosidase Inhibitors, Letters in Drug Design and Discovery (2021)
20. A New Route to the Synthesis of 2-Hydrazolyl-4-Thiazolidinone Hybrids, Evaluation of Α-Glucosidase Inhibitory Activity and Molecular Modeling Insights, Heliyon (2024)