Oxidative Stress As a Possible Mechanism of Statin-Induced Myopathy

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Oxidative Stress As a Possible Mechanism of Statin-Induced Myopathy Publisher Pubmed

Ahmadi Y^{1, 2} ; Ghorbanihaghjo A² ; Naghizadeh M³ ; Yagin NL⁴

Source: Inflammopharmacology Published:2018

Abstract

Statins, inhibitors of hydroxy methyl glutaryl coenzyme-A (HMG-CoA) reductase, are the most widely used drugs for treating hypercholesterolemia. However, statins can cause disabling myopathy as their main adverse effect. Several molecular mechanisms underlie the statin-induced myopathy including the decrease in the levels of essential mevalonate and cholesterol derivatives. This review discusses a further mechanism involving the loss of other anti-oxidant defenses besides ubiquinone (Co-Q) in skeletal muscles which produce a significant amount of reactive oxygen species (ROS). Therefore, to maintain their function, skeletal muscles need a high level of anti-oxidants. © 2018, Springer International Publishing AG, part of Springer Nature.

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Style	Citing Format
MLA	Ahmadi Y, et al.. "Oxidative Stress As a Possible Mechanism of Statin-Induced Myopathy." Inflammopharmacology, vol. 26, no. 3, 2018, pp. 667-674.
APA	Ahmadi Y, Ghorbanihaghjo A, Naghizadeh M, Yagin NL (2018). Oxidative Stress As a Possible Mechanism of Statin-Induced Myopathy. Inflammopharmacology, 26(3), 667-674.
Chicago	Ahmadi Y, Ghorbanihaghjo A, Naghizadeh M, Yagin NL. "Oxidative Stress As a Possible Mechanism of Statin-Induced Myopathy." Inflammopharmacology 26, no. 3 (2018): 667-674.
Harvard	Ahmadi Y et al. (2018) 'Oxidative Stress As a Possible Mechanism of Statin-Induced Myopathy', Inflammopharmacology, 26(3), pp. 667-674.
Vancouver	Ahmadi Y, Ghorbanihaghjo A, Naghizadeh M, Yagin NL. Oxidative Stress As a Possible Mechanism of Statin-Induced Myopathy. Inflammopharmacology. 2018;26(3):667-674.
BibTex	@article{ author = {Ahmadi Y and Ghorbanihaghjo A and Naghizadeh M and Yagin NL}, title = {Oxidative Stress As a Possible Mechanism of Statin-Induced Myopathy}, journal = {Inflammopharmacology}, volume = {26}, number = {3}, pages = {667-674}, year = {2018} }
RIS	TY - JOUR AU - Ahmadi Y AU - Ghorbanihaghjo A AU - Naghizadeh M AU - Yagin NL TI - Oxidative Stress As a Possible Mechanism of Statin-Induced Myopathy JO - Inflammopharmacology VL - 26 IS - 3 SP - 667 EP - 674 PY - 2018 ER -

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