Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Prevention of Abdominal Adhesion by a Polycaprolactone/Phospholipid Hybrid Film Containing Quercetin and Silver Nanoparticles Publisher Pubmed



Hosseinpourmoghadam R1 ; Rabbani S2 ; Mahboubi A1 ; Tabatabai SA3 ; Haeri A1, 4
Authors

Source: Nanomedicine Published:2021


Abstract

Aim: To develop quercetin-loaded poly(caprolactone) (PCL)/soybean phosphatidylcholine (PC) films coated with silver (Ag) to prevent the formation of postoperative adhesions (POA). Materials methods: Films were prepared using the solvent casting method, coated with Ag, and underwent in vitro tests. In vivo studies were conducted employing an animal model of sidewall defect and cecum abrasion. Results: Films showed sustained release behavior of quercetin and Ag. Coating films with Ag improved their antimicrobial activity. In vivo studies confirmed superior antiadhesion properties of films compared with the control groups evaluated by gross observation, histochemical staining and immunohistochemistry analyses. Conclusion: Ag-Q-PCL-PC films are a potential candidate to prevent POA by acting as a sustained release delivery system and physical barrier. © 2021 Future Medicine Ltd.
Related Docs
View other Related Docs
1. Recent Advances in the Preventative Strategies for Postoperative Adhesions Using Biomaterial-Based Membranes and Micro/Nano-Drug Delivery Systems, Journal of Drug Delivery Science and Technology (2023)
2. Hyaluronic Acid Gel Incorporating Curcumin-Phospholipid Complex Nanoparticles Prevents Postoperative Peritoneal Adhesion, Journal of Pharmaceutical Sciences (2023)
3. Indomethacin Sustained-Release Anti-Adhesion Membrane Composed of a Phospholipid and Polycaprolactone Blend, Iranian Journal of Pharmaceutical Research (2022)
Experts (# of related papers)
View all Related Experts
Shahram Rabbani (6)
Hamid Akbari Javar (2)
Other Related Docs
4. Curcumin Polymeric Membranes for Postoperative Peritoneal Adhesion: Comparison of Nanofiber Vs. Film and Phospholipid-Enriched Vs. Non-Enriched Formulations, International Journal of Pharmaceutics (2022)
5. Novel Wound Dressing Based on Postbiotic/Chitosan Film Accelerates Cutaneous Wound Healing, Jundishapur Journal of Microbiology (2021)
6. Bridging Potential of Taurine-Loading Pcl Conduits Transplanted With Henscs on Resected Sciatic Nerves, Regenerative Therapy (2022)
7. Tannic Acid and Glutaraldehyde-Modified Hyaluronic Acid/Chitosan Films: A Synergistic Approach to Enhanced Mechanical, Degradative, and Biological Properties for Wound Dressings, Polymers for Advanced Technologies (2025)
8. Egg Shell-Derived Calcium Phosphate/Carbon Dot Nanofibrous Scaffolds for Bone Tissue Engineering: Fabrication and Characterization, Materials Science and Engineering C (2019)
9. Facile Preparation of a Novel Biogenic Silver-Loaded Nanofilm With Intrinsic Anti-Bacterial and Oxidant Scavenging Activities for Wound Healing, Scientific Reports (2020)
10. Chitosan-Based Layered Nanofibers Loaded With Herbal Extract As Wound-Dressing Materials on Wound Model Studies, Biointerface Research in Applied Chemistry (2019)
11. A Novel Mucoadhesive Film Containing Probiotic Extract for Oral Candidiasis Treatment: Formulation and Antifungal Evaluation, Microbial Pathogenesis (2024)
12. Anti-Biofouling Assembly Strategies for Protein & Cell Repellent Surfaces: A Mini-Review, Journal of Biomaterials Science# Polymer Edition (2021)
13. Preparation of Antibacterial Nanofiber Nanocomposites Based on Bacterial Cellulose, BioNanoScience (2025)
14. Drug-Loaded Electrospun Nanofibrous Sheets As Barriers Against Postsurgical Adhesions in Mice Model, Nanomedicine Research Journal (2017)
15. Preparation, Antioxidant, Antibacterial, and in Vivo Evaluation of Pomegranate Flower Extract Nanofibers Based on Thiolated Chitosan and Thiolated Gelatin for Treating Aphthous Stomatitis, Carbohydrate Polymers (2025)
16. Bone Tissue Engineering Using 3-D Polycaprolactone/Gelatin Nanofibrous Scaffold Containing Berberine: In Vivo and in Vitro Study, Polymers for Advanced Technologies (2022)
17. Designing Mucoadhesive Discs Containing Stem Bark Extract of Ziziphus Jujuba Based on Iranian Traditional Documents, Iranian Journal of Basic Medical Sciences (2016)
18. G-Csf Loaded Nanofiber/Nanoparticle Composite Coated With Collagen Promotes Wound Healing in Vivo, Journal of Biomedical Materials Research - Part A (2017)
19. In Situ Bone Tissue Engineering Using Gene Delivery Nanocomplexes, Acta Biomaterialia (2020)
20. Piperine Liposome-Embedded in Hyaluronan Hydrogel As an Effective Platform for Prevention of Postoperative Peritoneal Adhesion, Journal of Microencapsulation (2023)