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Molecular Biosensors for Detection of Mirna and Its Application in Medical Diagnosis Publisher



Dadmehr M ; Allahverdi M ; Kalat NK ; Sheikhnejad B ; Hosseini M
Authors

Source: TrAC - Trends in Analytical Chemistry Published:2026


Abstract

Regulatory microRNAs (miRNAs) are single-stranded RNA molecules, approximately 18–25 nucleotides in length, that do not code the proteins. They have gained attention as potential biomarkers for the diagnosis of cancer. Numerous biosensors have focused on development of point-of-care biosensors for the detection of miRNAs. Molecular biosensors had the potential to overcome the challenges include sample preparation, matrix effects and system integration in medical application. Several molecular strategies have been developed to address these challenges. The molecular strategies including HCR, RCA, LAMP, CHA, SDA and CRISPR are among the approaches that relies on the molecular detection in miRNA biosensors. In this review, we have described recent advancements in the field of molecular biosensors for detection of miRNAs, and also discuss and compare the feasibility and performance of different strategies applied in platform of the molecular biosensors. Also, applicability of proposed biosensors has been considered to compare their clinical results. © 2025 Elsevier B.V.
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