Prevalence and Types of Esophageal Motility Disorders in Patients With Chronic Cough Publisher



Zakaryaei M ; Aletaha N ; Azizpour A ; Kazemizadeh H ; Sahebi L ; Sadeghi A ; Alborzi F
Source: SN Comprehensive Clinical Medicine Published:2026

Abstract

Background: The present study was conducted with the aim of determining the prevalence and type of esophageal motility disorders in patients with chronic cough referred to Imam Khomeini Hospital. Methods: 23 patients with chronic cough (more than 8 weeks) and 23 patients with GERD without cough symptoms were included in the study. Manometry was done with MMS device and water perfused method. The results of manometry as well as demographic and clinical information were compared between people with chronic cough and the control group. All data were analyzed by SPSS software version 26 with a significance level of 0.05. Results: Gender, age, medication use, regurgitation, chest pain, dysphagia, laryngitis and dyspepsia were not significantly different between the two groups (p > 0.05). The frequency of heartburn (p = 0.001) and tooth decay (p = 0.003) in people with cough was significantly lower and higher than the control group, respectively. 78.3% of people with chronic cough had GERD. The prevalence of dysmotility and its type did not differ between the two groups. The frequency of Fragmented Peristalsis in people with cough was significantly higher than in the control group (p = 0.032). There was no significant difference in parameters such as LES or UES pressure and break size between the two groups (p > 0.05). Conclusion: Although the prevalence of dysmotility in patients with cough was not different from that of patients without cough, the increase in fragmented peristalsis can be considered effective factor in the occurrence of chronic cough. © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2026.