Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Placental Histopathological Changes and the Level of Anti-Spike Antibody After Covid-19 Vaccination During Pregnancy: A Case Series Publisher



Heidary Z1 ; Gargari OK2 ; Zakidizaji M3 ; Shafiee A2 ; Fathi H2 ; Saeednejad R4 ; Ghaemi M1 ; Hantoushzadeh S1
Authors

Source: Journal of Reproduction and Infertility Published:2024


Abstract

Background: COVID-19 infection during pregnancy could be associated with placental histopathological changes such as vascular diseases and malperfusion. There are studies showing that mRNA vaccines are not associated with significant placental pathological changes. Our objective was to evaluate the placental histopathology in pregnant women who received Sinopharm, an inactivated virus vaccine, during pregnancy. Case Presentation: The study included placental samples collected from mothers who gave birth of living singletons through elective cesarean sections performed between March 2022 and May 2022 at Imam Khomeini Hospital Complex. The study included women who had no history of positive reverse transcription polymerase chain reaction (RT-PCR) testing for COVID-19 during pregnancy, and had received at least one dose of COVID-19 vaccine during their pregnancy. Humoral levels of anti-SARS-CoV-2 spike IgG were measured in both the mothers and neonates. Results: The study included 20 mother-neonate pairs. The mean maternal age was 34±3.6 years, and all mothers received Sinopharm vaccine as their first and second doses. The last vaccine dose was administered during pregnancy, with 3 mothers receiving it in the first trimester, 9 in the second trimester, and 8 in the third trimester. The histopathological findings in the placental samples included decidual vasculopathy, subchorionic thrombosis, and chronic histiocytic intervillositis. All mothers and neonates, except one pair, were positive for anti-spike antibody. Conclusion: Multiple abnormal histopathological findings were reported in placenta of vaccinated mothers. However, similar to previous studies, these placental findings are considered mild lesions and have been observed in both vaccinated and unvaccinated mothers. Copyright © 2024, Journal of Reproduction & Infertility.
Related Docs
View other Related Docs
1. Evaluating the Newborn-Related Outcomes of Pregnancy After Covid-19 Sinopharm Vaccination, Archives of Pediatric Infectious Diseases (2025)
2. Cord Blood Antibodies Following Bbibp-Corv (Sinopharm) Vaccination During Pregnancy, Immunity# Inflammation and Disease (2023)
3. Pregnant Women and Infants Against the Infection Risk of Covid-19: A Review of Prenatal and Postnatal Symptoms, Clinical Diagnosis, Adverse Maternal and Neonatal Outcomes, and Available Treatments, Archives of Gynecology and Obstetrics (2022)
Experts (# of related papers)
View all Related Experts
Sedigheh Hantoushzadeh (3)
Nima Rezaei (2)
Other Related Docs
4. Covid-19 Infection in Iranian Pregnant Women: A Case Series of 25 Patients, Journal of Obstetrics# Gynecology and Cancer Research (2022)
5. Analysis of Maternal Coronavirus Infections and Neonates Born to Mothers With 2019-Ncov; a Systematic Review, Archives of Academic Emergency Medicine (2020)
6. Comparison of Obstetric and Neonatal Outcomes in Pregnant Women With and Without Covid-19 Infection: A Single-Center Prospective Cohort Study, Journal of Obstetrics, Gynecology and Cancer Research (2024)
7. The Severity of Covid-19 Among Pregnant Women and the Risk of Adverse Maternal Outcomes, International Journal of Gynecology and Obstetrics (2021)
8. Pathological Examination of the Placenta in Covid-19–Positive Mothers: A Short Communication, Iranian Journal of Pathology (2023)
9. Corona in Infants: New Drugs and Vaccinations for Mothers, Pakistan Journal of Medical and Health Sciences (2020)
10. Comparison of Igg Against Covid-19 Between Postmenopausal and Nonmenopausal Women Vaccinated With Sinopharm Vaccine, Lab Medicine (2023)
11. Confirming Vertical Fetal Infection With Coronavirus Disease 2019: Neonatal and Pathology Criteria for Early Onset and Transplacental Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 From Infected Pregnant Mothers, Archives of Pathology and Laboratory Medicine (2020)
12. Novel Coronavirus in a 15-Day-Old Neonate With Clinical Signs of Sepsis, a Case Report, Infectious Diseases (2020)
13. Side Effects and Short-Term Safety of Covid-19 Vaccines for Pregnant Women: A Case Study of Southeast Iran, Archives of Clinical Infectious Diseases (2023)
14. Sars-Cov-2: An Imperative Maternal-Fetal Concern, Iranian Journal of Microbiology (2021)
15. Neonatal Sars-Cov-2 Infection and Congenital Myocarditis: A Case Report and Literature Review, Archives of Pediatric Infectious Diseases (2020)
16. Impact of Covid-19 and Vaccination on First and Second Trimester Screening Results, Cytokine (2023)
17. Effect of Spikogen Subunit Vaccine Administration During Pregnancy on Fetal Development of Rats, Clinical and Experimental Vaccine Research (2024)
18. Care of Newborns Born to Mothers With Covid-19 Infection; a Review of Existing Evidence, Journal of Maternal-Fetal and Neonatal Medicine (2022)
19. Maternal and Neonatal Outcomes in Covid-19 Infected Pregnancies: A Prospective Cohort Study, Journal of Travel Medicine (2020)
20. Vertical Transmission and Maternal Passive Immunity Post-Sars-Cov-2, Future Virology (2023)