In Vitro Elimination of El4 Cancer Cells From Spermatogonia Stem Cells by Mirna-143- a Nd 206-Loaded Folic Acid-Conjugated Plga Nanoparticles

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In Vitro Elimination of El4 Cancer Cells From Spermatogonia Stem Cells by Mirna-143- a Nd 206-Loaded Folic Acid-Conjugated Plga Nanoparticles Publisher Pubmed

Shams A^{1, 2} ; Shabani R^{1, 2} ; Asgari H² ; Karimi M³ ; Najafi M⁴ ; Asgharijafarabadi M^{5, 6} ; Razavi SM⁷ ; Miri SR⁸ ; Abbasi M⁹ ; Mohammadi A² ; Koruji M^{1, 2}

Source: Nanomedicine Published:2022

Abstract

Aim: MiRNA's-143 and-206 are powerful apoptotic regulators in cancer cells. This study aimed to use miRNA-143- A nd 206-loaded poly(lactic-co-glycolic) acid (PLGA) nanoparticles conjugated with folic acid to induce apoptosis in the EL4 cancer cells. Materials & methods: The therapy was conducted in six groups: Treatment with both miRNAs simultaneously (mixed miRNAs), miRNA-206 treatment, miRNA-143 treatment, blank PLGA, blank polyethylenimine (PEI) and complex PEI-miRNAs. Results: In terms of viability, in mixed miRNAs no synergistic effect was observed on EL4 cell elimination. However, in the single miRNA-206 group, a stronger apoptotic effect was observed than the mixed miRNAs group and single miRNA-143 group alone. Conclusion: MiRNAs' apoptotic induction effects in cancer cells were found to be remarkable. © 2022 Future Medicine Ltd.

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Style	Citing Format
MLA	Shams A, et al.. "In Vitro Elimination of El4 Cancer Cells From Spermatogonia Stem Cells by Mirna-143- a Nd 206-Loaded Folic Acid-Conjugated Plga Nanoparticles." Nanomedicine, vol. 17, no. 8, 2022, pp. 531-545.
APA	Shams A, Shabani R, Asgari H, Karimi M, Najafi M, Asgharijafarabadi M, Razavi SM, Miri SR, Abbasi M, Mohammadi A, Koruji M (2022). In Vitro Elimination of El4 Cancer Cells From Spermatogonia Stem Cells by Mirna-143- a Nd 206-Loaded Folic Acid-Conjugated Plga Nanoparticles. Nanomedicine, 17(8), 531-545.
Chicago	Shams A, Shabani R, Asgari H, Karimi M, Najafi M, Asgharijafarabadi M, Razavi SM, et al.. "In Vitro Elimination of El4 Cancer Cells From Spermatogonia Stem Cells by Mirna-143- a Nd 206-Loaded Folic Acid-Conjugated Plga Nanoparticles." Nanomedicine 17, no. 8 (2022): 531-545.
Harvard	Shams A et al. (2022) 'In Vitro Elimination of El4 Cancer Cells From Spermatogonia Stem Cells by Mirna-143- a Nd 206-Loaded Folic Acid-Conjugated Plga Nanoparticles', Nanomedicine, 17(8), pp. 531-545.
Vancouver	Shams A, Shabani R, Asgari H, Karimi M, Najafi M, Asgharijafarabadi M, et al.. In Vitro Elimination of El4 Cancer Cells From Spermatogonia Stem Cells by Mirna-143- a Nd 206-Loaded Folic Acid-Conjugated Plga Nanoparticles. Nanomedicine. 2022;17(8):531-545.
BibTex	@article{ author = {Shams A and Shabani R and Asgari H and Karimi M and Najafi M and Asgharijafarabadi M and Razavi SM and Miri SR and Abbasi M and Mohammadi A and Koruji M}, title = {In Vitro Elimination of El4 Cancer Cells From Spermatogonia Stem Cells by Mirna-143- a Nd 206-Loaded Folic Acid-Conjugated Plga Nanoparticles}, journal = {Nanomedicine}, volume = {17}, number = {8}, pages = {531-545}, year = {2022} }
RIS	TY - JOUR AU - Shams A AU - Shabani R AU - Asgari H AU - Karimi M AU - Najafi M AU - Asgharijafarabadi M AU - Razavi SM AU - Miri SR AU - Abbasi M AU - Mohammadi A AU - Koruji M TI - In Vitro Elimination of El4 Cancer Cells From Spermatogonia Stem Cells by Mirna-143- a Nd 206-Loaded Folic Acid-Conjugated Plga Nanoparticles JO - Nanomedicine VL - 17 IS - 8 SP - 531 EP - 545 PY - 2022 ER -

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