Margins of Planning Target Volume and Set-Up Errors Based on Megavoltage Conebeam Ct Image Guided Radiotherapy With Helical Tomotherapy: Importance of Automatic Registration Plus Manual Registration

Margins of Planning Target Volume and Set-Up Errors Based on Megavoltage Conebeam Ct Image Guided Radiotherapy With Helical Tomotherapy: Importance of Automatic Registration Plus Manual Registration Publisher

Makrani DS ; Banaee N ; Geraily G ; Nedaie HA ; Moghaddam AK ; Jassim HH

Source: Journal of Biomedical Physics and Engineering Published:2026

Abstract

Background: Helical Tomotherapy (HT) enables daily verification of patient positioning using Megavoltage Computed Tomography (MVCT) during each treatment session. Objective: The present study aimed to investigate the effects of Automatic Registration (AR) compared to a combination of Automatic and Manual Registration (AR+MR) on setup errors. Additionally, the study aimed to determine the corresponding Margins of the Planning Target Volume (MPTV). Material and Methods: In this experimental study, a total of 1513 daily MVCT scans were analyzed from September 2020 to January 2024, which were obtained from 71 patients diagnosed with Head and Neck (HN), cervical, and gastrointestinal cancer. The scans were registered with the planning CT to determine the setup errors of the patients. The analysis compares the setup errors between the AR and the AR+MR techniques in translational (X, Y, and Z axes) and rotational directions (RX, RY, and RZ). Additionally, the study calculated the MPTV. Results: In the AR and AR+MR techniques, the translational setup errors were significantly different in the Z-axis for HN patients. For cervical cancer patients, AR and AR+MR exhibited significantly different translational errors across all axes. Furthermore, they also had notable differences in the Y and Z-axis translational errors for Gastro-Intestinal (GI) patients. Regarding the rotational setup errors, a substantial difference was observed in the Z-axis translational error for cervical cancer patients, and in the Y and Z-axes for GI patients. Conclusion: Human assessment after automatic registration helps ensure that the registration is clinically appropriate, especially in circumstances involving deformable patient anatomy. © Journal of Biomedical Physics and Engineering.

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Style	Citing Format
MLA	Makrani DS, et al.. "Margins of Planning Target Volume and Set-Up Errors Based on Megavoltage Conebeam Ct Image Guided Radiotherapy With Helical Tomotherapy: Importance of Automatic Registration Plus Manual Registration." Journal of Biomedical Physics and Engineering, vol. 16, no. 1, 2026, pp. 57-70.
APA	Makrani DS, Banaee N, Geraily G, Nedaie HA, Moghaddam AK, Jassim HH (2026). Margins of Planning Target Volume and Set-Up Errors Based on Megavoltage Conebeam Ct Image Guided Radiotherapy With Helical Tomotherapy: Importance of Automatic Registration Plus Manual Registration. Journal of Biomedical Physics and Engineering, 16(1), 57-70.
Chicago	Makrani DS, Banaee N, Geraily G, Nedaie HA, Moghaddam AK, Jassim HH. "Margins of Planning Target Volume and Set-Up Errors Based on Megavoltage Conebeam Ct Image Guided Radiotherapy With Helical Tomotherapy: Importance of Automatic Registration Plus Manual Registration." Journal of Biomedical Physics and Engineering 16, no. 1 (2026): 57-70.
Harvard	Makrani DS et al. (2026) 'Margins of Planning Target Volume and Set-Up Errors Based on Megavoltage Conebeam Ct Image Guided Radiotherapy With Helical Tomotherapy: Importance of Automatic Registration Plus Manual Registration', Journal of Biomedical Physics and Engineering, 16(1), pp. 57-70.
Vancouver	Makrani DS, Banaee N, Geraily G, Nedaie HA, Moghaddam AK, Jassim HH. Margins of Planning Target Volume and Set-Up Errors Based on Megavoltage Conebeam Ct Image Guided Radiotherapy With Helical Tomotherapy: Importance of Automatic Registration Plus Manual Registration. Journal of Biomedical Physics and Engineering. 2026;16(1):57-70.
BibTex	@article{ author = {Makrani DS and Banaee N and Geraily G and Nedaie HA and Moghaddam AK and Jassim HH}, title = {Margins of Planning Target Volume and Set-Up Errors Based on Megavoltage Conebeam Ct Image Guided Radiotherapy With Helical Tomotherapy: Importance of Automatic Registration Plus Manual Registration}, journal = {Journal of Biomedical Physics and Engineering}, volume = {16}, number = {1}, pages = {57-70}, year = {2026} }
RIS	TY - JOUR AU - Makrani DS AU - Banaee N AU - Geraily G AU - Nedaie HA AU - Moghaddam AK AU - Jassim HH TI - Margins of Planning Target Volume and Set-Up Errors Based on Megavoltage Conebeam Ct Image Guided Radiotherapy With Helical Tomotherapy: Importance of Automatic Registration Plus Manual Registration JO - Journal of Biomedical Physics and Engineering VL - 16 IS - 1 SP - 57 EP - 70 PY - 2026 ER -

Style

Citing Format

MLA

Makrani DS, et al.. "Margins of Planning Target Volume and Set-Up Errors Based on Megavoltage Conebeam Ct Image Guided Radiotherapy With Helical Tomotherapy: Importance of Automatic Registration Plus Manual Registration." Journal of Biomedical Physics and Engineering, vol. 16, no. 1, 2026, pp. 57-70.

APA

Makrani DS, Banaee N, Geraily G, Nedaie HA, Moghaddam AK, Jassim HH (2026). Margins of Planning Target Volume and Set-Up Errors Based on Megavoltage Conebeam Ct Image Guided Radiotherapy With Helical Tomotherapy: Importance of Automatic Registration Plus Manual Registration. Journal of Biomedical Physics and Engineering, 16(1), 57-70.

Chicago

Makrani DS, Banaee N, Geraily G, Nedaie HA, Moghaddam AK, Jassim HH. "Margins of Planning Target Volume and Set-Up Errors Based on Megavoltage Conebeam Ct Image Guided Radiotherapy With Helical Tomotherapy: Importance of Automatic Registration Plus Manual Registration." Journal of Biomedical Physics and Engineering 16, no. 1 (2026): 57-70.

Harvard

Makrani DS et al. (2026) 'Margins of Planning Target Volume and Set-Up Errors Based on Megavoltage Conebeam Ct Image Guided Radiotherapy With Helical Tomotherapy: Importance of Automatic Registration Plus Manual Registration', Journal of Biomedical Physics and Engineering, 16(1), pp. 57-70.

Vancouver

Makrani DS, Banaee N, Geraily G, Nedaie HA, Moghaddam AK, Jassim HH. Margins of Planning Target Volume and Set-Up Errors Based on Megavoltage Conebeam Ct Image Guided Radiotherapy With Helical Tomotherapy: Importance of Automatic Registration Plus Manual Registration. Journal of Biomedical Physics and Engineering. 2026;16(1):57-70.

BibTex

@article{ author = {Makrani DS and Banaee N and Geraily G and Nedaie HA and Moghaddam AK and Jassim HH}, title = {Margins of Planning Target Volume and Set-Up Errors Based on Megavoltage Conebeam Ct Image Guided Radiotherapy With Helical Tomotherapy: Importance of Automatic Registration Plus Manual Registration}, journal = {Journal of Biomedical Physics and Engineering}, volume = {16}, number = {1}, pages = {57-70}, year = {2026} }

RIS

TY - JOUR
AU - Makrani DS
AU - Banaee N
AU - Geraily G
AU - Nedaie HA
AU - Moghaddam AK
AU - Jassim HH
TI - Margins of Planning Target Volume and Set-Up Errors Based on Megavoltage Conebeam Ct Image Guided Radiotherapy With Helical Tomotherapy: Importance of Automatic Registration Plus Manual Registration
JO - Journal of Biomedical Physics and Engineering
VL - 16
IS - 1
SP - 57
EP - 70
PY - 2026
ER -

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