The Rs16944 Snp in Il-1B and Risk of Polycystic Ovarian Syndrome Publisher



Salehgargari S¹ ; Ghafourifard S² ; Zandieh Z³ ; Ansaripour S⁴ ; Pouresmaeili F⁵ ; Vatannejad A^{6, 7}
Source: Gene Reports Published:2019

Abstract

Polycystic ovary syndrome (PCOS) is the most common endocrine condition in females during the reproductive years. Several genetic factors have been shown to impact the normal ovulation and be involved in the pathogenesis of PCOS. Genes regulating immune responses are among these factors. In the current investigation, we genotyped a variant in Interleukin (IL)-1B gene (rs16944) in 270 patients with PCOS (including 154 infertile cases (PCOS-I) and 116 cases with history of recurrent abortion (PCOS-A)) and 112 healthy controls. There was no significant difference in frequencies of rs16944 alleles/genotypes between PCOS-I subjects and healthy controls. However, the G allele of the rs16944 SNP was less frequent among PCOS-A cases compared with controls (OR (95% CI) = 0.58 (0.4–0.84), P value = 0.004). The rs16944 SNP was associated with PCOS-A in co-dominant (GG vs. AA: OR (95% CI) = 0.37 (0.18–0.76), P value = 0.02), dominant (AG + GG vs. AA: OR (95% CI) = 0.51 (0.28–0.91), P value = 0.02) and recessive (GG vs. AG + AA: OR (95% CI) = 0.50 (0.27–0.92), P value = 0.02) models. Taken together, the mentioned SNP can be regarded as a risk locus for a certain type of PCOS in Iranian population. © 2019 Elsevier Inc.