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Synthesis of the Olanzapine Labeled by Carbon-14 Publisher Pubmed



Saadatjoo N1 ; Javaheri M1, 2 ; Saemian N2 ; Amini M3
Authors

Source: Journal of Labelled Compounds and Radiopharmaceuticals Published:2016


Abstract

Olanzapine is one of the most widely used antipsychotic drugs, which acts as an antagonist for multiple neurotransmitter receptor sites. 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno [2,3-b][1,5] benzodiazepine (Olanzapine) labeled with carbon-14 in the four positions has been synthesized as part of a three-step sequence from 2-amino-5-methylthiophene-3-carbonitrile-[carbonitrile-14C]. Copyright © 2016 John Wiley & Sons, Ltd.
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