Thioflavin T Effect in Diabetic Wistar Rats: Reporting the Antihyperglycemic Property of an Amyloid Probing Dye

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Thioflavin T Effect in Diabetic Wistar Rats: Reporting the Antihyperglycemic Property of an Amyloid Probing Dye Publisher Pubmed

Najafian M¹ ; Amini S² ; Dehestani B³ ; Parivar K⁴ ; Ebrahimhabibi A^{3, 5}

Source: Pharmacological Reports Published:2015

Abstract

Background Thioflavin T (ThT) is a well-known probe of amyloid fibrils with a benzothiazole core structure. As a compound with partial inhibitory effect on alpha-amylase, the results of oral ThT administration were investigated on a streptozotocin (STZ)-induced rat model of diabetes. Methods STZ was administered intraperitoneally for induction of diabetes. Afterwards, doses of 2, 8, 16, and 32 mg/kg of ThT were used in diabetic and non-diabetic rats. Blood glucose levels, lipid profiles, alpha-amylase activity, food and water intake and urine volume were assessed. Docking was also performed to evaluate the inhibitory effect of ThT on alpha-amylase. Results Upon treatment with ThT, blood glucose levels and lipid profile of diabetic rats improved significantly. Furthermore, alpha-amylase serum levels of treated animals decreased compared to the control group, suggesting a possible effect of ThT on this digestive enzyme. On the other hand, the food intake of treated animals showed a decrease. ThT effects were also seen to some extent in the non-diabetic group. Conclusion ThT is suggested to be a potentially useful compound in treatment and prevention of diabetes and associated complications. © 2014 Institute of Pharmacology, Polish Academy of Sciences.

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Style	Citing Format
MLA	Najafian M, et al.. "Thioflavin T Effect in Diabetic Wistar Rats: Reporting the Antihyperglycemic Property of an Amyloid Probing Dye." Pharmacological Reports, vol. 67, no. 2, 2015, pp. 364-369.
APA	Najafian M, Amini S, Dehestani B, Parivar K, Ebrahimhabibi A (2015). Thioflavin T Effect in Diabetic Wistar Rats: Reporting the Antihyperglycemic Property of an Amyloid Probing Dye. Pharmacological Reports, 67(2), 364-369.
Chicago	Najafian M, Amini S, Dehestani B, Parivar K, Ebrahimhabibi A. "Thioflavin T Effect in Diabetic Wistar Rats: Reporting the Antihyperglycemic Property of an Amyloid Probing Dye." Pharmacological Reports 67, no. 2 (2015): 364-369.
Harvard	Najafian M et al. (2015) 'Thioflavin T Effect in Diabetic Wistar Rats: Reporting the Antihyperglycemic Property of an Amyloid Probing Dye', Pharmacological Reports, 67(2), pp. 364-369.
Vancouver	Najafian M, Amini S, Dehestani B, Parivar K, Ebrahimhabibi A. Thioflavin T Effect in Diabetic Wistar Rats: Reporting the Antihyperglycemic Property of an Amyloid Probing Dye. Pharmacological Reports. 2015;67(2):364-369.
BibTex	@article{ author = {Najafian M and Amini S and Dehestani B and Parivar K and Ebrahimhabibi A}, title = {Thioflavin T Effect in Diabetic Wistar Rats: Reporting the Antihyperglycemic Property of an Amyloid Probing Dye}, journal = {Pharmacological Reports}, volume = {67}, number = {2}, pages = {364-369}, year = {2015} }
RIS	TY - JOUR AU - Najafian M AU - Amini S AU - Dehestani B AU - Parivar K AU - Ebrahimhabibi A TI - Thioflavin T Effect in Diabetic Wistar Rats: Reporting the Antihyperglycemic Property of an Amyloid Probing Dye JO - Pharmacological Reports VL - 67 IS - 2 SP - 364 EP - 369 PY - 2015 ER -

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